Paramsothy Y, Collins M, Lawrence C M
Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, U.K.
Br J Dermatol. 1988 Jun;118(6):783-9. doi: 10.1111/j.1365-2133.1988.tb02596.x.
The effect of UVB therapy after short contact dithranol therapy (SCDT) was examined in 53 patients with psoriasis. After dithranol application, patients were randomly allocated to receive either a tar bath and UVB therapy (27 patients) or an emulsifying ointment bath only (26 patients). Forty eight patients completed the study; 16 of the 21 dithranol only patients cleared in a mean of 19.5 days compared with 20 of the 27 dithranol + UVB patients who cleared in a mean of 20.3 days. These differences were not significant. Similarly there was no significant difference in response between the dithranol only and dithranol UVB group as measured by the change in plaque thickness measured using Harpenden calipers, and the severity of psoriasis assessed by the extent of the rash, the degree of scaling, redness and induration. Thirteen of the 16 dithranol only patients who cleared relapsed in a mean of 10.6 weeks compared with 14 of the 20 dithranol UVB patients who relapsed after a mean of 18.9 weeks (P less than 0.05). Comparison of pre- and post-treatment full blood count, biochemical screen and urinalysis showed no evidence of systemic toxicity due to SCDT. This study shows that UVB therapy does not improve the clearance of psoriasis in SCDT, but does significantly postpone relapse.
对53例银屑病患者进行了短期接触蒽林疗法（SCDT）后紫外线B（UVB）疗法效果的研究。涂抹蒽林后，患者被随机分为两组，一组接受焦油浴和UVB疗法（27例患者），另一组仅接受乳化软膏浴（26例患者）。48例患者完成了研究；21例仅接受蒽林治疗的患者中有16例在平均19.5天内病情缓解，而27例接受蒽林+UVB治疗的患者中有20例在平均20.3天内病情缓解。这些差异不显著。同样，通过使用Harpenden卡尺测量斑块厚度的变化以及根据皮疹范围、鳞屑程度、发红和硬结程度评估的银屑病严重程度来衡量，仅接受蒽林治疗组和蒽林+UVB治疗组之间的反应也没有显著差异。16例仅接受蒽林治疗且病情缓解的患者中有13例在平均10.6周后复发，相比之下，20例接受蒽林+UVB治疗且病情缓解的患者中有14例在平均18.9周后复发（P小于0.05）。治疗前后全血细胞计数、生化检查和尿液分析的比较显示，没有证据表明SCDT会导致全身毒性。这项研究表明，UVB疗法并不能改善SCDT中银屑病的清除情况，但确实能显著推迟复发。
