Grattan C E, Christopher A P, Robinson M, Cowan M A
Department of Dermatology, General Hospital, Birmingham, U.K.
Br J Dermatol. 1988 Nov;119(5):623-6. doi: 10.1111/j.1365-2133.1988.tb03473.x.
Twenty four of 30 patients with chronic plaque psoriasis completed a double-blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis.
30例慢性斑块状银屑病患者中有24例完成了一项双盲随机配对比较，比较了拉萨尔糊剂中的地蒽酚与拉萨尔糊剂中的地蒽酚和氟轻松。使用地蒽酚和氟轻松混合物治疗的一侧银屑病严重程度下降更快，但两侧最终清除时间无差异。使用地蒽酚和氟轻松治疗的一侧烧灼感发作较少，但皮肤染色更明显。在随后随访长达3个月的20例患者中，11例在使用地蒽酚和氟轻松治疗的一侧复发更多，2例在仅使用地蒽酚治疗的一侧复发，7例无明显差异。得出的结论是，在传统的地蒽酚治疗方案中添加局部类固醇可使银屑病更快地初步清除且烧灼感减轻，但银屑病复发更快。
