Human Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, Luxembourg.
L'Oréal Research and Innovation, 1 avenue Eugène Schueller BP22, 93601 Aulnay sous Bois, France.
Environ Int. 2018 Dec;121(Pt 2):1341-1354. doi: 10.1016/j.envint.2018.10.056. Epub 2018 Nov 9.
Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants from activities such as transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels of PAH exposure are considered critical regarding public health issues. The possibility to detect PAH and PAH metabolites biologically incorporated in human hair was demonstrated and proposed as biomarkers of exposure. Nevertheless, the possibility to distinguish different levels of exposure between different populations is still needed to validate the relevance of hair analysis in epidemiological studies. In this work, hair samples were collected from 204 women from two cities in China based on one year Air Quality Index history from governmental data (Baoding as polluted city and Dalian less polluted city). 8 out of the 15 parent PAH and 7 out of the 56 metabolites analyzed in this study were detected in all the samples. The highest concentrations in hair were observed for phenanthrene (4.2 to 889 pg/mg) > fluoranthene (1.05 to 204 pg/mg) > pyrene (3.2 to 124 pg/mg) for parent PAH, and for 9-OH-fluorene (0.04 to 1.78 pg/mg) > 2-OH-naphthalene (0.68 to 811 pg/mg) > 1-OH-anthracene (0.24 to 10.9 pg/mg) for metabolites. 14 parent PAH and 15 metabolites presented a significantly higher concentration in the hair samples collected from Baoding, as compared to Dalian. The median concentration of parent PAH was from 1.5 to 2.8 times higher in the hair of the subjects from Baoding than in subjects from Dalian and that of PAH metabolites was from 1 to 2.3 times higher. The study of inter-chemical associations revealed similarities and differences between the two areas, suggesting common and different sources of exposure depending on PAH respectively. The results confirmed the relevance of hair analysis to identify qualitative and quantitative differences in PAH exposure between populations from different areas. This study is the first one to investigate both parent PAH and their metabolites in a biological matrix.
多环芳烃（PAH）是有机物不完全燃烧产生的，作为污染物从交通、木材燃烧、燃煤电厂等活动中释放到环境中。在世界上许多城市，PAH 的暴露水平被认为对公共健康问题至关重要。已经证明并提出可以检测生物体内摄入的 PAH 和 PAH 代谢物，并将其作为暴露的生物标志物。然而，仍然需要区分不同人群之间的不同暴露水平，以验证头发分析在流行病学研究中的相关性。在这项工作中，根据政府数据（保定为污染城市，大连为污染较少的城市）的一年空气质量指数历史，从中国的两个城市收集了 204 名女性的头发样本。在所分析的 15 种母体 PAH 和 56 种代谢物中，有 8 种在所有样本中都有检测到。头发中含量最高的母体 PAH 是菲（4.2 至 889 pg/mg）>荧蒽（1.05 至 204 pg/mg）>芘（3.2 至 124 pg/mg），代谢物中含量最高的是 9-OH-芴（0.04 至 1.78 pg/mg）>2-OH-萘（0.68 至 811 pg/mg）>1-OH-蒽（0.24 至 10.9 pg/mg）。与大连相比，保定采集的头发样本中，14 种母体 PAH 和 15 种代谢物的浓度明显更高。保定组母体 PAH 的中位数浓度比大连组高 1.5 至 2.8 倍，PAH 代谢物的中位数浓度比大连组高 1 至 2.3 倍。化学物质间关联的研究揭示了两个地区之间的相似性和差异性，表明根据 PAH 分别存在共同和不同的暴露源。研究结果证实了头发分析在识别不同地区人群 PAH 暴露的定性和定量差异方面的相关性。这项研究首次在生物基质中同时研究了母体 PAH 及其代谢物。
