a Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan , Tashkent , Uzbekistan.
b Division of Chemistry of Renewables, Department of Chemistry , University of Natural Resources and Life Sciences, Vienna (BOKU University) , Tulln , Austria.
Nat Prod Res. 2019 Aug;33(15):2169-2175. doi: 10.1080/14786419.2018.1490901. Epub 2018 Nov 13.
A new flavone glucoside, 4',5-dihydroxy-3',5',6-trimethoxyflavone-7--β-D-glucoside was obtained from aerial parts of , together with the known flavone eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl fraction.
从地上部分中得到了一种新的黄酮葡萄糖苷，4',5-二羟基-3',5',6-三甲氧基黄酮-7--β-D-葡萄糖苷，以及已知的黄酮芹菜素（5,7-二羟基-3',4',6-三甲氧基黄酮）。这些化合物通过 IR、UV、NMR 和 HR-MS 进行了全面的分析鉴定，并确定了它们的化学结构。显示出最强的 DPPH 自由基清除能力以及还原能力（在 CUPRAC 和 FRAP 测定中）和磷钼酸盐活性的是乙酸乙酯部分。该部分对酪氨酸酶也表现出最强的抑制作用。此外，芹菜素和 CHCl 部分表现出最好的抗糖尿病作用。
