Kapp Daniel L, Rogers Montanah, Hermans Michel H E
1 Jupiter Medical Center, Jupiter, FL, USA.
2 Florida Atlantic University, Boca Raton, FL, USA.
Int J Low Extrem Wounds. 2018 Dec;17(4):295-300. doi: 10.1177/1534734618804037. Epub 2018 Nov 13.
Necrotizing fasciitis is the generic term for a series of progressive gangrenous infections of the skin and subcutaneous tissues. Typically, necrotizing fasciitis start with an, often small, infected lesion with atypical symptoms, which then quickly develops into a rapidly spreading, massive infection. The primary therapy is excision of all necrotic tissue in combination with treatment of systemic symptoms such as shock. The defects resulting from rigorous excision are often very large. Once they are clean, they require closure with an autograft. This article reviews the symptoms and treatment of necrotizing fasciitis. In addition, it illustrates, with 2 cases, how a hyaluronic-based extracellular matrix can be used to "fill in" with neodermis for the lost dermis and can create a wound bed most suitable for grafting.
坏死性筋膜炎是皮肤和皮下组织一系列进行性坏疽性感染的统称。通常，坏死性筋膜炎始于一个往往较小的、有非典型症状的感染病灶，然后迅速发展为快速蔓延的大规模感染。主要治疗方法是切除所有坏死组织并治疗休克等全身症状。严格切除造成的缺损往往非常大。一旦创面清洁，就需要用自体移植进行闭合。本文回顾了坏死性筋膜炎的症状和治疗方法。此外，通过2个病例说明了基于透明质酸的细胞外基质如何用于为缺失的真皮“填充”新真皮，并能创建最适合移植的创面床。
