Stegelmeier B L, Bottoms G D, Denicola D B, Reed W M
Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Cornell Vet. 1988 Jul;78(3):221-30.
Twelve dogs were randomly divided into three groups. Group 1 dogs were given Escherichia coli endotoxin and then treated with flunixin meglumine. Group 2 dogs were given endotoxin as group 1, but untreated. Group 3 dogs were given flunixin meglumine alone. The dogs were monitored clinically and urine and serum samples were collected at regular intervals for 72 hours. All surviving dogs were humanely killed after 72 hours and examined for gross and histologic lesions. Group 1 dogs all survived 72 hours, but showed prerenal azotemia, hepatocellular damage, hemorrhagic enteritis, and numerous gastric ulcerations. Three of the four dogs in group 2 died before 72 hours. Group 2 dogs showed many of the same chemical and hemodynamic changes as group 1. They had severe hemorrhage into the intestinal lumen; however, there were no gastric ulcerations. Group 3 dogs all survived and showed little physical or hematologic change. The study suggested the following: 1) flunixin meglumine was an effective drug in ameliorating the fatal effects of canine endotoxemia, 2) the effects of endotoxin in combination with flunixin meglumine, at 1.1 mg/kg body weight, caused gastric ulcerations, and 3) in normal dogs flunixin meglumine at 1.1 mg/kg body weight did not cause severe side effects or gross lesions.
12只狗被随机分为三组。第1组的狗先给予大肠杆菌内毒素，然后用氟尼辛葡甲胺治疗。第2组的狗与第1组一样给予内毒素，但不进行治疗。第3组的狗仅给予氟尼辛葡甲胺。对这些狗进行临床监测，并每隔一定时间采集尿液和血清样本，持续72小时。所有存活的狗在72小时后被人道处死，并检查大体和组织学损伤情况。第1组的狗全部存活72小时，但出现肾前性氮质血症、肝细胞损伤、出血性肠炎和多处胃溃疡。第2组的4只狗中有3只在72小时前死亡。第2组的狗出现了许多与第1组相同的化学和血流动力学变化。它们的肠腔内有严重出血；然而，没有胃溃疡。第3组的狗全部存活，身体和血液学变化很小。该研究表明：1）氟尼辛葡甲胺是一种有效药物，可改善犬内毒素血症的致命影响；2）内毒素与1.1毫克/千克体重的氟尼辛葡甲胺联合使用会导致胃溃疡；3）在正常狗中，1.1毫克/千克体重的氟尼辛葡甲胺不会引起严重副作用或大体损伤。
