Hardie E M, Kolata R J, Rawlings C A
Circ Shock. 1983;11(2):159-73.
The efficacy of treating acute lethal peritonitis with flunixin meglumine was investigated in dogs. Following intraperitoneal administration of Escherichia coli organisms in a sterile fecal suspension, eight dogs were left untreated and eight dogs were treated with flunixin meglumine (2.2 mg/kg) at 15 min and 12 hr. Another eight dogs were treated with flunixin meglumine (2.2 mg/kg) at 15 minutes and 12 hours, and with gentamicin sulfate (2.2 mg/kg) at 15 min, 6 hr, 12 hr, and 18 hr postsepsis. Untreated dogs lived 5-12 hr and rapidly developed fever, hypoglycemia, metabolic acidosis, hypotension, and cardiac dysfunction. Dogs treated with flunixin meglumine had longer survival times (9-24 hr), lower body temperatures, higher stroke indexes, higher mean arterial pressures, and higher blood pH values than untreated dogs. Six of the eight dogs treated with flunixin meglumine and gentamicin sulfate lived 24 hr. Compared to untreated controls, dogs in this group had slower development of hypoglycemia, lower body temperatures, higher stroke volumes, higher mean arterial pressures, and only temporary development of metabolic acidosis.
在犬类中研究了氟尼辛葡甲胺治疗急性致死性腹膜炎的疗效。在无菌粪便悬液中腹腔注射大肠杆菌后，8只犬未接受治疗，8只犬在15分钟和12小时时接受氟尼辛葡甲胺（2.2毫克/千克）治疗。另外8只犬在15分钟和12小时时接受氟尼辛葡甲胺（2.2毫克/千克）治疗，并在脓毒症发生后15分钟、6小时、12小时和18小时接受硫酸庆大霉素（2.2毫克/千克）治疗。未治疗的犬存活5 - 12小时，并迅速出现发热、低血糖、代谢性酸中毒、低血压和心脏功能障碍。接受氟尼辛葡甲胺治疗的犬比未治疗的犬存活时间更长（9 - 24小时），体温更低，每搏指数更高，平均动脉压更高，血液pH值更高。8只接受氟尼辛葡甲胺和硫酸庆大霉素治疗的犬中有6只存活了24小时。与未治疗的对照组相比，该组犬低血糖发展较慢，体温较低，每搏量较高，平均动脉压较高，仅出现短暂的代谢性酸中毒。
