Hardie E M, Rawlings C A, Shotts E B, Waltman D W, Rakich P M
Am J Vet Res. 1987 Jan;48(1):56-62.
Twelve dogs were infused with 10(10) Escherichia coli/kg of body weight through a portal vein catheter over a 1-hour period; 6 dogs were treated with flunixin meglumine (1 mg/kg) 15 minutes after the infusion had begun. Six dogs (controls) were infused with a comparable volume of sterile saline solution over the same period. Over a 4-hour monitoring period, nontreated septicemic dogs developed systemic hypotension, decreased cardiac output, increased portal pressure, increased serum alanine transaminase values, increased extravascular liver water, increased liver glycogen depletion, and decreased arterial oxygen tension compared with control dogs. Accumulations of polymorphonuclear leukocytes and E coli were found in the livers and lungs of septicemic dogs. Flunixin meglumine treatment prevented systemic hypotension and hypoxemia, reversed the early but not the late stages of portal hypertension, and decreased E coli concentrations in the lungs. Other effects of treatment were not noticed.
通过门静脉导管在1小时内给12只狗输注每千克体重10(10)个大肠杆菌；6只狗在输注开始15分钟后用氟尼辛葡甲胺（1毫克/千克）进行治疗。6只狗（对照组）在同一时期输注相同体积的无菌盐溶液。在4小时的监测期内，与对照狗相比，未经治疗的败血症狗出现全身性低血压、心输出量减少、门静脉压力升高、血清丙氨酸转氨酶值升高、血管外肝水增加、肝糖原消耗增加以及动脉血氧张力降低。在败血症狗的肝脏和肺中发现多形核白细胞和大肠杆菌的聚集。氟尼辛葡甲胺治疗可预防全身性低血压和低氧血症，逆转门静脉高压的早期但非晚期阶段，并降低肺中大肠杆菌的浓度。未观察到治疗的其他效果。
