Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.
PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan.
Sci Rep. 2018 Nov 13;8(1):16727. doi: 10.1038/s41598-018-35067-2.
We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
作为一种肝源因子，硒蛋白 P（SELENOP）在小鼠中与胰岛素抵抗和胰岛素分泌受损的发生发展有关，其是否与人类未来发生高血糖有关。76 名健康、非妊娠的人类受试者在基线和 4 年随访时进行口服葡萄糖耐量试验（OGTT）。9 名受试者在随访时出现葡萄糖耐量受损或 2 型糖尿病。在基线时，SELENOP 浓度与胰岛素生成指数呈负相关，但与稳态模型评估-估计的胰岛素抵抗（HOMA-IR）无关。多变量分析表明，SELENOP 基线浓度可独立于其他参数预测随访时的空腹血糖。受试者工作特征（ROC）曲线分析表明，SELENOP 血清基线浓度是预测葡萄糖耐量未来发生的可靠指标，而硒则不然。总之，在一般日本人群中，循环 SELENOP 水平升高，而不是循环硒水平升高，与葡萄糖耐量未来发生呈正相关且独立相关。
