根治性切除术后腹膜后脂肪肉瘤患者术前淋巴细胞/单核细胞比值的预后意义
Prognostic significance of pretreatment lymphocyte/monocyte ratio in retroperitoneal liposarcoma patients after radical resection.
作者信息
Luo Peng, Cai Weiluo, Yang Lingge, Chen Shiqi, Wu Zhiqiang, Chen Yong, Zhang Ruming, Shi Yingqiang, Yan Wangjun, Wang Chunmeng
机构信息
Department of Bone and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China,
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China,
出版信息
Cancer Manag Res. 2018 Oct 18;10:4727-4734. doi: 10.2147/CMAR.S171602. eCollection 2018.
BACKGROUND
The aim of this study was to evaluate the prognostic value of pretreatment inflammatory biomarkers in retroperitoneal liposarcoma (RPLS) patients after radical resection.
PATIENTS AND METHODS
One hundred patients with RPLS who underwent radical resection between September 2004 and October 2010 at Fudan University Shanghai Cancer Center were included in this study. Laboratory tests of peripheral blood were sampled before surgery. The optimal cutoff values of systemic inflammatory markers were defined by receiver-operating curve analyses. Curves of disease-free survival (DFS) and overall survival (OS) were obtained by the Kaplan-Meier method. Cox proportional hazards regression modeling was used to perform univariate and multivariate analyses.
RESULTS
The median follow-up time was 53 months. The median DFS and OS were 27 and 86 months, respectively. On the basis of the optimal cutoff value of 3, 24 patients were classified into low lymphocyte/monocyte ratio (LMR) group and 76 patients into high LMR group. In univariate analysis, low LMR group had significantly shorter DFS (<0.001) and OS (<0.001) compared to high LMR group. In multivariate analysis, low LMR was demonstrated as an independent negative prognostic factor for both DFS (HR=2.854, 95% CI=1.392-5.851, =0.004) and OS (HR=3.897, 95% CI=1.681-9.033, =0.002).
CONCLUSION
Pretreatment LMR is a useful prognostic marker in RPLS patients after radical resection.
背景
本研究旨在评估根治性切除术后腹膜后脂肪肉瘤（RPLS）患者术前炎症生物标志物的预后价值。
患者与方法
本研究纳入了2004年9月至2010年10月在复旦大学附属上海肿瘤医院接受根治性切除的100例RPLS患者。术前采集外周血进行实验室检查。通过受试者工作特征曲线分析确定全身炎症标志物的最佳临界值。采用Kaplan-Meier法绘制无病生存期（DFS）和总生存期（OS）曲线。使用Cox比例风险回归模型进行单因素和多因素分析。
结果
中位随访时间为53个月。中位DFS和OS分别为27个月和86个月。根据最佳临界值3，将24例患者分为低淋巴细胞/单核细胞比值（LMR）组，76例患者分为高LMR组。单因素分析显示，低LMR组的DFS（<0.001）和OS（<0.001）显著短于高LMR组。多因素分析表明，低LMR是DFS（HR=2.854，95%CI=1.392-5.851，P=0.004）和OS（HR=3.897，95%CI=1.681-9.033，P=0.002）的独立阴性预后因素。
结论
术前LMR是RPLS患者根治性切除术后有用的预后标志物。
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