Laing V B, Sheretz E F, Flowers F P
Department of Medicine (Dermatology), University of Florida College of Medicine, JHMHC, Gainesville 32610.
J Am Acad Dermatol. 1988 Jul;19(1 Pt 1):91-4. doi: 10.1016/s0190-9622(88)70156-5.
We report two patients who had a bullous eruption limited to the lower extremities when first seen by us. Clinically the eruption resembled limited bullous pemphigoid. In both patients the onset of the eruption was associated with ibuprofen therapy, and lesions promptly resolved after discontinuing the ibuprofen. This type of presentation has not been reported previously as an adverse effect of ibuprofen. Bullous reactions to nonsteroidal anti-inflammatory agents are briefly reviewed.
我们报告了两名患者，初次就诊时均有仅局限于下肢的大疱性皮疹。临床上，该皮疹类似于局限性大疱性类天疱疮。两名患者的皮疹发作均与布洛芬治疗有关，停用布洛芬后皮损迅速消退。此前尚未有将这种表现报告为布洛芬不良反应的情况。本文简要综述了非甾体抗炎药引起的大疱反应。
