Alcalay J, David M, Ingber A, Hazaz B, Sandbank M
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
J Am Acad Dermatol. 1988 Feb;18(2 Pt 1):345-9. doi: 10.1016/s0190-9622(88)70050-x.
Three young and middle-aged patients developed severe bullous eruption after receiving various penicillins. The clinical findings included high fever, prostration, widespread bullous eruption mainly on the head, face, and extremities, targetlike lesions on the palms and soles, and severe erosions in almost all the mucous membranes. Direct and indirect immunofluorescence studies were those of bullous pemphigoid. Complete clearing of the eruption occurred with prednisone therapy. We conclude that drug-induced bullous pemphigoid is a different entity from the classic bullous pemphigoid.
三名中青年患者在使用各种青霉素后出现严重的大疱性皮疹。临床症状包括高热、虚脱、主要发生在头面部和四肢的广泛大疱性皮疹、手掌和脚底的靶样损害以及几乎所有黏膜的严重糜烂。直接和间接免疫荧光检查结果符合大疱性类天疱疮。使用泼尼松治疗后皮疹完全消退。我们得出结论，药物性大疱性类天疱疮是一种与经典大疱性类天疱疮不同的疾病。
