Detti Laura, Christiansen Mary E, Francillon Ludwig, Ikuwezunma Gini, Diamond Michael P, Mari Giancarlo, Tobiasz Ana M
a Department of Obstetrics and Gynecology, Rout Center , University of Tennessee Health Science Center , Memphis , TN , USA.
b Department of Obstetrics and Gynecology , Augusta University , Augusta , GA , USA.
Syst Biol Reprod Med. 2019 Apr;65(2):147-154. doi: 10.1080/19396368.2018.1537385. Epub 2018 Nov 14.
We sought to determine serum AMH levels in the maternal circulation, and the umbilical artery and vein, in normal women and women with PCOS, and their neonates at time of delivery. This represents a cross-sectional study of 57 pregnant patients who presented to the labor and delivery suite and subsequently delivered. We obtained maternal, as well as fetal blood from both, umbilical artery and vein. We measured serum concentrations of estradiol, AMH, testosterone and FSH. A total of 30 patients delivered a female and 27 a male neonate. Of them, 18/30 and 18/27 had a diagnosis of PCOS by NIH criteria. Mean age, BMI, weight gain in pregnancy, and gestational age did not differ between the two groups of mothers. AMH serum levels were statistically higher in women with PCOS (p < 0.005) and in their fetuses, independently of gender. Testosterone was higher in women with PCOS (p < 0.001), but there was no PCOS-related difference in their fetuses. FSH levels were significantly lower in PCOS than non-PCOS mothers carrying a male (p = 0.022), but not a female, fetus. AMH was positively correlated with maternal serum testosterone (p = 0.001) and negatively with fetal serum FSH (p < 0.026). In PCOS pregnancies, AMH was negatively correlated with maternal BMI (p = 0.019), menstrual cycle length (p = 0.035), and fetal uterine vein FSH (p = 0.021). In conclusion, at time of delivery, fetuses of women with PCOS had higher AMH levels and similar testosterone levels compared to fetuses from non-PCOS mothers, irrespective of gender. Our results may help explaining developmental differences in offspring of PCOS women.
我们试图测定正常女性和多囊卵巢综合征（PCOS）女性及其分娩时新生儿的母血循环、脐动脉和脐静脉中的血清抗苗勒管激素（AMH）水平。这是一项对57名到产房就诊并随后分娩的孕妇进行的横断面研究。我们采集了母体以及胎儿脐动脉和脐静脉的血液。我们测量了血清雌二醇、AMH、睾酮和促卵泡生成素（FSH）的浓度。共有30名患者分娩了女婴，27名患者分娩了男婴。其中，根据美国国立卫生研究院（NIH）标准，18/30的产妇和18/27的产妇被诊断为PCOS。两组母亲的平均年龄、体重指数（BMI）、孕期体重增加和孕周没有差异。PCOS女性及其胎儿的AMH血清水平在统计学上更高（p < 0.005），与性别无关。PCOS女性的睾酮水平更高（p < 0.001），但其胎儿中不存在与PCOS相关的差异。携带男胎的PCOS母亲的FSH水平显著低于非PCOS母亲（p = 0.022），但携带女胎时无此差异。AMH与母体血清睾酮呈正相关（p = 0.001），与胎儿血清FSH呈负相关（p < 0.026）。在PCOS妊娠中，AMH与母体BMI呈负相关（p = 0.019）、与月经周期长度呈负相关（p = 0.035）、与胎儿子宫静脉FSH呈负相关（p = 0.021）。总之，在分娩时，PCOS女性的胎儿与非PCOS母亲的胎儿相比，AMH水平更高，睾酮水平相似，与性别无关。我们的结果可能有助于解释PCOS女性后代的发育差异。
