Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology , Soochow University , Suzhou 215123 , China.
Department of Cardiothoracic Surgery , Wuxi People's Hospital Affiliated to Nanjing Medical University , Wuxi 214023 , China.
Bioconjug Chem. 2019 Feb 20;30(2):305-324. doi: 10.1021/acs.bioconjchem.8b00750. Epub 2018 Nov 26.
Protein/peptide drugs possess unique advantages, such as high pharmacological potency, molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use in cancer therapy. In the past decades, great achievements have been made in protein delivery systems, which can protect cargo proteins against detrimental physiological environments and efficiently deliver proteins into tumor sites and cells. In this Review, we first summarize the existing protein/peptide drugs used for cancer treatment, illustrate their anti-tumor mechanisms, and point out the potential challenges/barriers against their medical utility. We then discuss the existing strategies for protein encapsulation/conjugation and survey recent advances in the development of protein delivery vehicles, including lipid-based membrane nanocarriers, polymeric carriers, metal-organic frameworks, inorganic carriers, protein/peptide-based nanocarriers, and DNA nanostructures. The design strategies, advantages in potentiating protein delivery efficiencies, and possible limitations of these delivery systems are also discussed. Finally, future opportunities and challenges in anti-cancer protein/peptide delivery are indicated.
蛋白质/肽类药物具有独特的优势，如高药理效力、分子特异性、多功能性和低毒性，因此在癌症治疗中有很大的应用潜力。在过去的几十年中，蛋白质递送系统取得了巨大的进展，能够保护货物蛋白免受有害的生理环境的影响，并将蛋白质有效地递送到肿瘤部位和细胞中。在这篇综述中，我们首先总结了用于癌症治疗的现有蛋白质/肽类药物，阐述了它们的抗肿瘤机制，并指出了它们在医学应用方面的潜在挑战/障碍。然后我们讨论了蛋白质包封/缀合的现有策略，并调查了蛋白质递送载体的最新进展，包括基于脂质的膜纳米载体、聚合物载体、金属有机框架、无机载体、蛋白质/肽类纳米载体和 DNA 纳米结构。还讨论了这些递送系统的设计策略、增强蛋白质递送效率的优势以及可能存在的局限性。最后，指出了抗癌蛋白质/肽类药物递送的未来机遇和挑战。
