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Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology.射血分数保留的心力衰竭中心功能障碍和衰竭:机制与管理。代表欧洲心脏病学会心力衰竭协会的立场声明。
Eur J Heart Fail. 2018 Jan;20(1):16-37. doi: 10.1002/ejhf.1029. Epub 2017 Oct 16.
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Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials.吡格列酮与心血管疾病的二级预防。一项随机对照试验的荟萃分析。
Cardiovasc Diabetol. 2017 Oct 16;16(1):134. doi: 10.1186/s12933-017-0617-4.
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Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.肠道微生物群代谢产物与主要不良心血管疾病事件及死亡风险:前瞻性研究的系统评价和荟萃分析
J Am Heart Assoc. 2017 Jun 29;6(7):e004947. doi: 10.1161/JAHA.116.004947.
4
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Arq Bras Cardiol. 2015 Nov;105(5):510-8. doi: 10.5935/abc.20150113. Epub 2015 Sep 25.
5
Reduced Right Ventricular Function Predicts Long-Term Cardiac Re-Hospitalization after Cardiac Surgery.右心室功能降低预示心脏手术后的长期心脏再住院情况。
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Prognostic value of right ventricular two-dimensional global strain in patients referred for cardiac surgery.右心室二维整体应变在心脏手术患者中的预后价值。
J Am Soc Echocardiogr. 2013 Jul;26(7):721-6. doi: 10.1016/j.echo.2013.03.021. Epub 2013 Apr 25.
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Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography.成人右心超声心动图评估指南:美国超声心动图学会报告,得到欧洲心脏病学会注册分支欧洲超声心动图协会以及加拿大超声心动图学会认可。
J Am Soc Echocardiogr. 2010 Jul;23(7):685-713; quiz 786-8. doi: 10.1016/j.echo.2010.05.010.
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The Vascular Study Group of New England Cardiac Risk Index (VSG-CRI) predicts cardiac complications more accurately than the Revised Cardiac Risk Index in vascular surgery patients.新英格兰心血管风险指数(VSG-CRI)血管外科患者的血管研究小组预测心脏并发症比修订后的心血管风险指数更准确。
J Vasc Surg. 2010 Sep;52(3):674-83, 683.e1-683.e3. doi: 10.1016/j.jvs.2010.03.031. Epub 2010 Jun 8.
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Perioperative cardiac damage in vascular surgery patients.血管外科患者围手术期心脏损伤。
Eur J Vasc Endovasc Surg. 2010 Jul;40(1):1-8. doi: 10.1016/j.ejvs.2010.03.014. Epub 2010 Apr 18.
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Prediction of major adverse cardiac events in vascular surgery: are cardiac risk scores of any practical value?血管外科手术中主要不良心脏事件的预测:心脏风险评分有实际价值吗?
Vasc Endovascular Surg. 2010 Jan;44(1):14-9. doi: 10.1177/1538574409349320. Epub 2009 Oct 14.

对于非急诊大血管手术的高危患者,术前存在右心室功能障碍与术后更高的心脏并发症发生率和更长的住院时间相关。

Preexisting Right Ventricular Dysfunction Is Associated With Higher Postoperative Cardiac Complications and Longer Hospital Stay in High-Risk Patients Undergoing Nonemergent Major Vascular Surgery.

机构信息

Department of Anesthesiology and Perioperative Care, University of California Irvine, Irvine, CA.

Department of Anesthesiology and Perioperative Care, University of California Irvine, Irvine, CA.

出版信息

J Cardiothorac Vasc Anesth. 2019 May;33(5):1279-1286. doi: 10.1053/j.jvca.2018.10.011. Epub 2018 Oct 13.

DOI:10.1053/j.jvca.2018.10.011
PMID:30429063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6628888/
Abstract

OBJECTIVES

To evaluate whether the presence of preexisting right ventricular (RV) dysfunction in high-risk patients undergoing nonemergent major vascular surgery is associated independently with higher incidents of postoperative cardiac complications and a longer length of hospital stay.

DESIGN

Retrospective chart review.

SETTING

Single-center university hospital setting.

PARTICIPANTS

The patient population consisted of those identified as American Society of Anesthesiologists classification III and above who had a preoperative echocardiogram within 1 year of undergoing nonemergent major vascular surgery between January 2010 and May 2017.

MEASUREMENTS AND MAIN RESULTS

After multivariate analyses, RV dysfunction (RVD) is associated independently with a higher incidence of postoperative major cardiac complications with an odds ratio = 6.3 (95% confidence interval [CI], 1.0-38.5; p = 0.046). In addition, patients with RVD had a 50% longer length of stay than those without RVD (incident rate ratio [95% CI], 1.5 [1.2-1.8]; p < 0.001).

CONCLUSION

In this retrospective study of high-risk patients undergoing major vascular surgery, RV dysfunction was associated independently with a higher incidence of postoperative major cardiovascular events and longer length of hospital stays. Based on current findings, the prognostic value of RVD extends beyond the cardiac surgical cohort. Knowledge in management of patients with RVD in the perioperative setting should be understood by all anesthesiologists. Of note, a future study with a larger sample size is needed to validate the current findings given the small sample size of this study.

摘要

目的

评估高危患者在非紧急大血管手术后是否存在预先存在的右心室(RV)功能障碍,是否与术后心脏并发症发生率较高和住院时间延长独立相关。

设计

回顾性图表审查。

地点

单中心大学医院。

参与者

患者人群包括美国麻醉医师学会分类 III 级及以上的患者,他们在 2010 年 1 月至 2017 年 5 月期间接受非紧急大血管手术后 1 年内接受过术前超声心动图检查。

测量和主要结果

多变量分析后,RV 功能障碍(RVD)与术后主要心脏并发症的发生率独立相关,优势比为 6.3(95%置信区间 [CI],1.0-38.5;p=0.046)。此外,与无 RVD 的患者相比,RVD 患者的住院时间延长了 50%(发生率比 [95%CI],1.5 [1.2-1.8];p<0.001)。

结论

在这项对接受大血管手术的高危患者的回顾性研究中,RV 功能障碍与术后主要心血管事件发生率较高和住院时间延长独立相关。基于目前的研究结果,RVD 的预后价值超出了心脏手术队列。所有麻醉师都应该了解 RVD 患者围手术期管理的知识。值得注意的是,鉴于本研究样本量较小,需要进一步开展更大样本量的研究来验证目前的研究结果。