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对于非急诊大血管手术的高危患者,术前存在右心室功能障碍与术后更高的心脏并发症发生率和更长的住院时间相关。

Preexisting Right Ventricular Dysfunction Is Associated With Higher Postoperative Cardiac Complications and Longer Hospital Stay in High-Risk Patients Undergoing Nonemergent Major Vascular Surgery.

机构信息

Department of Anesthesiology and Perioperative Care, University of California Irvine, Irvine, CA.

Department of Anesthesiology and Perioperative Care, University of California Irvine, Irvine, CA.

出版信息

J Cardiothorac Vasc Anesth. 2019 May;33(5):1279-1286. doi: 10.1053/j.jvca.2018.10.011. Epub 2018 Oct 13.

Abstract

OBJECTIVES

To evaluate whether the presence of preexisting right ventricular (RV) dysfunction in high-risk patients undergoing nonemergent major vascular surgery is associated independently with higher incidents of postoperative cardiac complications and a longer length of hospital stay.

DESIGN

Retrospective chart review.

SETTING

Single-center university hospital setting.

PARTICIPANTS

The patient population consisted of those identified as American Society of Anesthesiologists classification III and above who had a preoperative echocardiogram within 1 year of undergoing nonemergent major vascular surgery between January 2010 and May 2017.

MEASUREMENTS AND MAIN RESULTS

After multivariate analyses, RV dysfunction (RVD) is associated independently with a higher incidence of postoperative major cardiac complications with an odds ratio = 6.3 (95% confidence interval [CI], 1.0-38.5; p = 0.046). In addition, patients with RVD had a 50% longer length of stay than those without RVD (incident rate ratio [95% CI], 1.5 [1.2-1.8]; p < 0.001).

CONCLUSION

In this retrospective study of high-risk patients undergoing major vascular surgery, RV dysfunction was associated independently with a higher incidence of postoperative major cardiovascular events and longer length of hospital stays. Based on current findings, the prognostic value of RVD extends beyond the cardiac surgical cohort. Knowledge in management of patients with RVD in the perioperative setting should be understood by all anesthesiologists. Of note, a future study with a larger sample size is needed to validate the current findings given the small sample size of this study.

摘要

目的

评估高危患者在非紧急大血管手术后是否存在预先存在的右心室(RV)功能障碍,是否与术后心脏并发症发生率较高和住院时间延长独立相关。

设计

回顾性图表审查。

地点

单中心大学医院。

参与者

患者人群包括美国麻醉医师学会分类 III 级及以上的患者,他们在 2010 年 1 月至 2017 年 5 月期间接受非紧急大血管手术后 1 年内接受过术前超声心动图检查。

测量和主要结果

多变量分析后,RV 功能障碍(RVD)与术后主要心脏并发症的发生率独立相关,优势比为 6.3(95%置信区间 [CI],1.0-38.5;p=0.046)。此外,与无 RVD 的患者相比,RVD 患者的住院时间延长了 50%(发生率比 [95%CI],1.5 [1.2-1.8];p<0.001)。

结论

在这项对接受大血管手术的高危患者的回顾性研究中,RV 功能障碍与术后主要心血管事件发生率较高和住院时间延长独立相关。基于目前的研究结果,RVD 的预后价值超出了心脏手术队列。所有麻醉师都应该了解 RVD 患者围手术期管理的知识。值得注意的是,鉴于本研究样本量较小,需要进一步开展更大样本量的研究来验证目前的研究结果。

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