Borràs-Santos Alícia, Garcia-Aymerich Judith, Soler-Cataluña Juan José, Vigil Giménez Laura, Gea Guiral Joaquim, Rodríguez Chiaradía Diego, Pascual-Guardia Sergi, Marcos Rodríguez Pedro J, Alvarez Martinez Carlos J, Casanova Macario Ciro, López-Campos José Luis, Carrasco Hernández Laura, Martínez-González Cristina, Santos-Pérez Salud, Peces-Barba Germán, Molina Paris Jesús, Román Rodríguez Miguel, Barberà Joan Albert, Faner Rosa, Agustí Alvar, Cosío Borja G
ISGlobal, Barcelona, España; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, España.
ISGlobal, Barcelona, España; Universitat Pompeu Fabra (UPF), Barcelona, España; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, España.
Arch Bronconeumol (Engl Ed). 2019 Jun;55(6):312-318. doi: 10.1016/j.arbres.2018.09.007. Epub 2018 Nov 11.
Determinants of chronic obstructive pulmonary disease (COPD) in the early stages of its natural history are not well known. Improving our knowledge of these factors will help to design interventions that can modify prognosis. Study objectives are: a) to characterize a COPD population of young adults aged 35-50 years from a multidimensional point of view; b) to compare these patients with smokers with normal lung function; and c) to create a cohort of young adults aged 35-50 years (smokers or former smokers), with and without COPD, who will be followed in the future to improve understanding of the natural history of the disease.
This is a case-control multicenter study aimed at establishing a well-characterized cohort of young adults, smokers or former-smokers, with and without COPD, for subsequent follow-up. A total of 311 participants (101 cases and 210 controls) were selected from approximately 30 primary care settings and 12 hospitals in 8 Spanish regions. Subjects were smokers or former smokers (>10 pack-years) aged 35-50 years. Diagnosis of COPD was based on a post-bronchodilator result of FEV1/FVC<70%. The main study variables were: questionnaires on health, symptoms, exacerbations and daily physical activity, lung function tests, blood and sputum samples, and low-dose computed tomography. In the statistical analysis, COPD patient characteristics will be described and compared with control subjects using a logistic regression analysis.
慢性阻塞性肺疾病（COPD）自然史早期阶段的决定因素尚不明确。增进对这些因素的了解将有助于设计能够改善预后的干预措施。研究目标如下：a）从多维度角度对35至50岁的COPD青年人群进行特征描述；b）将这些患者与肺功能正常的吸烟者进行比较；c）建立一个由35至50岁（吸烟者或既往吸烟者）、患有或未患有COPD的青年成年人组成的队列，以便未来对其进行随访，从而加深对该疾病自然史的理解。
这是一项病例对照多中心研究，旨在建立一个特征明确的队列，纳入患有或未患有COPD的吸烟者或既往吸烟者（年龄在35至50岁之间），以便后续进行随访。从西班牙8个地区的约30个初级保健机构和12家医院中选取了311名参与者（101例病例和210名对照）。受试者为年龄在35至50岁之间的吸烟者或既往吸烟者（吸烟史超过10包年）。COPD的诊断基于支气管扩张剂使用后FEV1/FVC<70%的结果。主要研究变量包括：关于健康、症状、病情加重和日常体力活动的问卷、肺功能测试、血液和痰液样本，以及低剂量计算机断层扫描。在统计分析中，将使用逻辑回归分析描述COPD患者的特征并与对照受试者进行比较。
