一名未感染HIV的患者发生隐球菌抗原检测阴性的致死性脑膜炎。
Fatal meningitis with negative cryptococcal antigen test in a HIV-non-infected patient.
作者信息
Eshwara Vandana Kalwaje, Garg Rahul, Chandrashekhar G Siddaramappa, Shaw Tushar, Mukhopadhyay Chiranjay
机构信息
Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Medicine, Adarsha Hospital, Udupi, Karnataka, India.
出版信息
Indian J Med Microbiol. 2018 Jul-Sep;36(3):439-440. doi: 10.4103/ijmm.IJMM_18_164.
Cryptococcus gattii predominantly causes central nervous system and pulmonary infection in both immunocompromised and immunocompetent patients with substantial morbidity. We report a case of rapidly fatal meningitis by C. gattii in an HIV-non-infected man with CD4 lymphopenia who tested negative for cryptococcal antigen. This case may serve as an alert to its wider occurrence and less explored risk factors.
加氏隐球菌主要在免疫功能低下和免疫功能正常的患者中引起中枢神经系统和肺部感染，且发病率较高。我们报告了一例在一名CD4淋巴细胞减少但未感染HIV的男性中由加氏隐球菌引起的快速致命性脑膜炎病例，该患者的隐球菌抗原检测呈阴性。该病例可能提醒人们注意其更广泛的发生情况以及尚未充分探索的危险因素。
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