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FBP1 的恢复抑制了肝癌中 Snail 诱导的上皮间质转化。

Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma.

机构信息

Department of Liver Surgery, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, 510080, Guangzhou, China.

Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 34 Huangtang Road, 514031, Meizhou, China.

出版信息

Cell Death Dis. 2018 Nov 14;9(11):1132. doi: 10.1038/s41419-018-1165-x.

DOI:10.1038/s41419-018-1165-x
PMID:30429463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6235921/
Abstract

Fructose-1,6-bisphosphatase (FBP1), one of the rate-limiting gluconeogenic enzymes, plays critical roles in several cancers and is treated as a tumour suppressor. However, its role in hepatocellular carcinoma (HCC) is unclear. Here, we demonstrated that FBP1 was significantly inhibited during Snail-induced epithelial to mesenchymal transition (EMT) and tissues in HCC. Restoration of FBP1 expression in HCC cancer cells suppressed EMT phenotype, tumour migration and tumour growth induced by Snail overexpression in SMMC-7721 cells. Gene set enrichment analyses revealed significantly enriched terms, including WNT, Notch, ESC, CSR and PDGF, in the group with high Snail and low FBP1 compared with those with low Snail and high FBP1. Low FBP1 expression was significantly correlated with higher AFP level, satellite nodules, portal vein tumour thrombus, and advanced tumour stage. Survival analyses showed that FBP1 was an independent prognostic factor for overall survival and recurrence-free survival. In conclusion, our study revealed a vital role for FBP1 in Snail-induced EMT and prognostic prediction in HCC.

摘要

果糖-1,6-二磷酸酶（FBP1）是限速糖异生酶之一，在多种癌症中发挥关键作用，被视为肿瘤抑制因子。然而，其在肝细胞癌（HCC）中的作用尚不清楚。在这里，我们证明在 SNAI1 诱导的上皮间质转化（EMT）和 HCC 组织中，FBP1 显著受到抑制。在 SMMC-7721 细胞中，过表达 SNAI1 诱导的 EMT 表型、肿瘤迁移和肿瘤生长被 FBP1 表达的恢复所抑制。基因集富集分析显示，在高 SNAI1 和低 FBP1 组与低 SNAI1 和高 FBP1 组相比，显著富集了 WNT、Notch、ESC、CSR 和 PDGF 等相关基因。低 FBP1 表达与较高的 AFP 水平、卫星结节、门静脉癌栓和晚期肿瘤分期显著相关。生存分析表明，FBP1 是 HCC 患者总生存和无复发生存的独立预后因素。总之，我们的研究揭示了 FBP1 在 SNAI1 诱导的 EMT 以及 HCC 预后预测中的重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/da86f5cb82c8/41419_2018_1165_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/685d7b5d6603/41419_2018_1165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/30f3062fcd13/41419_2018_1165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/500585059cdf/41419_2018_1165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/a854651fff7d/41419_2018_1165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/031b1b83a370/41419_2018_1165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/da86f5cb82c8/41419_2018_1165_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/685d7b5d6603/41419_2018_1165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/30f3062fcd13/41419_2018_1165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/500585059cdf/41419_2018_1165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/a854651fff7d/41419_2018_1165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/031b1b83a370/41419_2018_1165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c1/6235921/da86f5cb82c8/41419_2018_1165_Fig6_HTML.jpg

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