Dańczak-Pazdrowska Aleksandra, Polańska Adriana, Synakiewicz Joanna, Gurgul Edyta, Molińska-Glura Marta, Ruchała Marek, Żaba Ryszard, Adamski Zygmunt
Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland.
Postepy Dermatol Alergol. 2018 Oct;35(5):470-473. doi: 10.5114/ada.2018.75839. Epub 2018 Jul 19.
Morphea, also known as localized scleroderma, is an autoimmune skin disease which is characterized by excessive accumulation of collagen that leads to the thickening of the dermis and subcutaneous tissue. There is an unclear relationship between morphea and other autoimmune diseases, especially related to the thyroid gland.
To determine the occurrence of increased antithyroid antibodies in patients with morphea in relation to the clinical manifestations of the disease.
Forty-two Caucasian patients with different forms of morphea were included into the study. To determine the thyroid status, thyrotropin (TSH), anti-peroxidase antibodies (TPO-Ab), anti-thyroglobulin antibodies (Tg-Ab) were evaluated with the use of the electrochemiluminescence method and TSH receptor autoantibodies (TRAb) - with the use of the radioimmunoassay method.
Increased levels of antithyroid antibodies were observed in 6 cases in relation to TPO-Ab (14.3%), in 4 cases in relation to of Tg-Ab (9.5%) and in 1 patient in relation to TRAb (2.3%). There was no difference in the level of antithyroid antibodies between circumscribed and generalized forms of morphea.
Although morphea is an autoimmune disease, it does not seem to be associated with increased prevalence of positive antithyroid antibodies. We conclude that there is no need to perform routine laboratory tests for thyroid disorders in patients with morphea.
硬斑病，也称为局限性硬皮病，是一种自身免疫性皮肤病，其特征是胶原蛋白过度积累，导致真皮和皮下组织增厚。硬斑病与其他自身免疫性疾病之间的关系尚不清楚，尤其是与甲状腺的关系。
确定硬斑病患者抗甲状腺抗体增加的发生率与疾病临床表现之间的关系。
42名患有不同形式硬斑病的白种人患者纳入研究。为确定甲状腺状态，采用电化学发光法评估促甲状腺激素（TSH）、抗过氧化物酶抗体（TPO-Ab）、抗甲状腺球蛋白抗体（Tg-Ab），采用放射免疫分析法评估促甲状腺激素受体自身抗体（TRAb）。
观察到6例患者的抗甲状腺抗体水平相对于TPO-Ab升高（14.3%），4例相对于Tg-Ab升高（9.5%），1例相对于TRAb升高（2.3%）。局限性和泛发性硬斑病患者的抗甲状腺抗体水平没有差异。
尽管硬斑病是一种自身免疫性疾病，但它似乎与抗甲状腺抗体阳性率增加无关。我们得出结论，硬斑病患者无需进行甲状腺疾病的常规实验室检查。
