Gurling H M
Academic Department of Psychiatry, University College, London.
J R Soc Med. 1988 Jun;81(6):332-4. doi: 10.1177/014107688808100610.
Crow's viral hypothesis of schizophrenia proposes that psychosis may be the result of mutagenesis caused by viral integration or transposition in human genomic DNA. Molecular genetic techniques can be used to systematically investigate this hypothesis. In a study of genomic lymphocyte DNA unexpected DNA polymorphisms which were probably insertions and deletions were found in specific human genomic retroviral (proviral) related sequences. However these changes were found exclusively in normal Icelandic individuals and are probably of evolutionary origin. The extent to which human retroviral insertion and deletion has taken place and the mobility of such sequences will help in understanding their evolutionary origin and might provide a source of polymorphic marker sequences that could be used in genetic linkage studies of disease.
克劳提出的精神分裂症病毒假说认为，精神病可能是病毒整合或转座导致人类基因组DNA发生诱变的结果。分子遗传学技术可用于系统地研究这一假说。在一项对基因组淋巴细胞DNA的研究中，在特定的人类基因组逆转录病毒（前病毒）相关序列中发现了意外的DNA多态性，这些多态性可能是插入和缺失。然而，这些变化仅在正常冰岛个体中发现，可能源于进化。人类逆转录病毒插入和缺失发生的程度以及此类序列的流动性将有助于理解它们的进化起源，并可能提供可用于疾病基因连锁研究的多态性标记序列来源。
