Department of Health Promotion and Behavioral Sciences, Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston, 7000 Fannin Street, UCT 2514, Houston, TX, 77030-5401, USA.
Faculty of Business and Law, Centre for Transformative Innovation, Swinburne University of Technology, Hawthorn, VIC, Australia.
AIDS Behav. 2019 Jul;23(7):1698-1707. doi: 10.1007/s10461-018-2327-7.
The objective of this study is to identify individual-level factors and health venue utilization patterns associated with uptake of pre-exposure prophylaxis (PrEP) and to evaluate whether PrEP uptake behavior is further diffused among young men who have sex with men (YMSM) through health venue referral networks. A sample of 543 HIV-seronegative YMSM aged 16-29 were recruited in 2014-2016 in Chicago, IL, and Houston, TX. Stochastic social network models were estimated to model PrEP uptake. PrEP uptake was associated with more utilization of health venues in Houston and higher levels of sexual risk behavior in Chicago. In Houston, both Hispanic and Black YMSM compared to White YMSM were less likely to take PrEP. No evidence was found to support the spread of PrEP uptake via referral networks, which highlights the need for more effective PrEP referral network systems to scale up PrEP implementation among at-risk YMSM.
本研究旨在确定与接受暴露前预防 (PrEP) 相关的个体因素和健康场所利用模式，并评估 PrEP 的采用行为是否通过健康场所转介网络在男男性行为者 (MSM) 中进一步扩散。2014 年至 2016 年期间，在伊利诺伊州芝加哥和德克萨斯州休斯顿招募了 543 名 HIV 血清阴性的 16-29 岁 MSM。采用随机社会网络模型来评估 PrEP 的采用情况。PrEP 的采用与休斯顿更多地利用健康场所以及芝加哥更高水平的性风险行为有关。在休斯顿，与白人 MSM 相比，西班牙裔和黑人 MSM 服用 PrEP 的可能性较低。没有证据支持通过转介网络传播 PrEP 的采用，这突出表明需要建立更有效的 PrEP 转介网络系统，以扩大高危 MSM 人群中 PrEP 的实施。
