Vazquez Luis Alberto, Calvo-Bonacho Eva, Reviriego Jesús, García-Margallo Teresa, Caveda Elena, Goday Albert
Hospital Universitario Marqués de Valdecilla, Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Av. Valdecilla, Santander, Spain.
Ibermutuamur, Mutua colaboradora con la Seguridad Social, Madrid, Spain.
Diabetes Ther. 2019 Feb;10(1):57-69. doi: 10.1007/s13300-018-0529-7. Epub 2018 Nov 14.
Our objective was to evaluate the incidence of type 2 diabetes mellitus (T2DM) in a working population in Spain and to assess associations between its development and several risk factors.
The ICARIA (Ibermutuamur CArdiovascular RIsk Assessment) cohort (n = 627,523) includes ~3% of Spanish workers. This analysis was undertaken in individuals whose glycaemic status during the index period (May 2004-December 2007) was determined to be normal or indicative of prediabetes [fasting plasma glucose (FPG) 100-125 mg/dl] and who had at least one FPG measurement taken 9 months after a first measurement during follow-up (May 2004-June 2014) (n = 380,366). T2DM patients were defined as those with an FPG ≥ 126 mg/day and those who had already been diagnosed with T2DM or were taking antihyperglycaemic medications.
The incidence rate of T2DM was 5.0 [95% confidence interval (CI) 4.9-5.1] cases per 1000 person-years. Under multivariate logistic regression analysis, the factor showing the strongest association with the occurrence of T2DM was the baseline FPG level, with the likelihood of T2DM almost doubling for every 5 mg/dl increase in baseline FPG between 100 and < 126 mg/dl. The presence of other cardiometabolic risk factors and being a blue-collar worker were also significantly associated with the occurrence of T2DM.
The incidence of T2DM in the working population was within the range encountered in the general population and prediabetes was found to be the strongest risk factor for the development of diabetes. The workplace is an appropriate and feasible setting for the assessment of easily measurable risk factors, such as the presence of prediabetes and other cardiometabolic factors, to facilitate the early detection of individuals at higher risk of diabetes and the implementation of diabetes prevention programmes.
Eli Lilly and Co.
我们的目标是评估西班牙劳动人口中2型糖尿病（T2DM）的发病率，并评估其发病与多种风险因素之间的关联。
ICARIA（伊比利亚互助心血管风险评估）队列（n = 627,523）包括约3%的西班牙工人。本分析纳入了在索引期（2004年5月至2007年12月）血糖状态被确定为正常或提示糖尿病前期[空腹血糖（FPG）100 - 125 mg/dl]，且在随访期间（2004年5月至2014年6月）首次测量后9个月至少进行过一次FPG测量的个体（n = 380,366）。T2DM患者定义为FPG≥126 mg/天以及那些已被诊断为T2DM或正在服用降糖药物的患者。
T2DM的发病率为每1000人年5.0例[95%置信区间（CI）4.9 - 5.1]。在多因素逻辑回归分析中，与T2DM发生关联最强的因素是基线FPG水平，在100至<126 mg/dl之间，基线FPG每升高5 mg/dl，T2DM发生的可能性几乎翻倍。其他心血管代谢风险因素的存在以及身为蓝领工人也与T2DM的发生显著相关。
劳动人口中T2DM的发病率在一般人群的发病范围内，且糖尿病前期被发现是糖尿病发生的最强风险因素。工作场所是评估易于测量的风险因素（如糖尿病前期和其他心血管代谢因素的存在）的合适且可行的环境，以便于早期发现糖尿病高危个体并实施糖尿病预防计划。
礼来公司
