Darwish Amira Hamed, Elgohary Tarek Mohamed, Nosair Nahla A
1 Pediatric Neurology Unit, Pediatrics, Tanta University Hospital, Faculty of Medicine, Tanta, Egypt.
2 Child Psychiatry Unit, Pediatrics, Tanta University Hospital, Faculty of Medicine, Tanta, Egypt.
J Child Neurol. 2019 Feb;34(2):61-67. doi: 10.1177/0883073818809831. Epub 2018 Nov 15.
Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children, but its specific etiology and pathophysiology are still incompletely understood.
This case-control study aimed to measure the level of serum interleukin-6 (IL-6) as a predictor of the immunologic status in children with ADHD, and to study its correlation with severity of symptoms.
60 ADHD children who met the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, criteria for ADHD and 60 control children were subjected to complete history taking, clinical examination, and psychometric tests. Serum interleukin-6 of ADHD patients and control children was measured by enzyme-linked immunosorbent assay.
The mean serum level of IL-6 was 22.35 (95% confidence interval [CI], 17.68-26.99) in ADHD patients, and it was 5.44 (95% CI, 4.81-6.06) in controls. A significantly higher level of IL-6 was reported in ADHD patients compared with controls ( P = .001). No significant correlation was found between serum IL-6 level and either the Intelligence Quotient (IQ) or the Conners' Parent Rating Scale score.
Serum IL-6 values were significantly higher in ADHD patients compared to healthy control children. Increased production of IL-6 may play a role in the pathogenesis of ADHD.
注意力缺陷多动障碍（ADHD）是儿童常见的神经行为障碍，但其具体病因和病理生理学仍未完全明确。
本病例对照研究旨在测量血清白细胞介素-6（IL-6）水平，作为ADHD儿童免疫状态的预测指标，并研究其与症状严重程度的相关性。
60例符合《精神疾病诊断与统计手册》第5版ADHD诊断标准的ADHD儿童和60例对照儿童接受了完整的病史采集、临床检查和心理测试。采用酶联免疫吸附测定法测量ADHD患者和对照儿童的血清白细胞介素-6。
ADHD患者血清IL-6的平均水平为22.35（95%置信区间[CI]，17.68 - 26.99），对照组为5.44（95%CI，4.81 - 6.06）。与对照组相比，ADHD患者的IL-6水平显著更高（P = .001）。血清IL-6水平与智商（IQ）或康纳斯父母评定量表评分之间均未发现显著相关性。
与健康对照儿童相比，ADHD患者的血清IL-6值显著更高。IL-6产生增加可能在ADHD的发病机制中起作用。
