a Department of Biology , University of Ottawa , Ottawa , Ontario , Canada.
b Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch , Health Canada , Ottawa , Canada.
Int J Environ Health Res. 2019 Jun;29(3):326-347. doi: 10.1080/09603123.2018.1543799. Epub 2018 Nov 15.
This study describes blood plasma concentrations of PCBs and p,p'-DDE in the Canadian population aged 20-79 years. PCBs and p,p'-DDE were measured in 1668 participants in the Canadian Health Measures Survey, Cycle 1 (2007-2009). We investigated how concentrations vary by sociodemographic, anthropometric, and lifestyle variables, identified factors associated with exposures, and evaluated concentrations against health-based guidance values. Congeners of PCB most commonly detected were PCB-138, PCB-153, and PCB-180. p,p'-DDE was detectable in > 99% of the samples. Factors associated with ∑PCBs were age, region of birth, frequency of fish consumption, and liver intake (R = 58.1%). For p,p'-DDE, significant factors were sex, age, region of birth, household education, and ethnic origin (R = 47.0%). PCB concentrations in Canadians were similar to those in the United States, and lower than those reported in Europe. A small percentage equalled or exceeded the Human Biomonitoring value of 3.5 µg/L for PCBs. Few exceedances of the p,p'-DDE biomonitoring equivalent were observed.
本研究描述了加拿大 20-79 岁人群的血浆中多氯联苯（PCBs）和 p,p'-DDE 的浓度。在加拿大健康测量调查（2007-2009 年周期 1）的 1668 名参与者中测量了 PCBs 和 p,p'-DDE。我们研究了浓度如何随社会人口统计学、人体测量学和生活方式变量而变化，确定了与暴露相关的因素，并根据基于健康的指导值评估了浓度。最常检测到的 PCB 同系物是 PCB-138、PCB-153 和 PCB-180。p,p'-DDE 在>99%的样本中可检测到。与∑PCBs 相关的因素有年龄、出生地、鱼类食用频率和肝脏摄入量（R=58.1%）。对于 p,p'-DDE，显著相关的因素是性别、年龄、出生地、家庭教育和种族（R=47.0%）。加拿大的 PCB 浓度与美国相似，低于欧洲报告的浓度。有一小部分浓度等于或超过了 3.5µg/L 的人体生物监测值。很少有 p,p'-DDE 生物监测等效物的超标。
