Salari S, Bagheri M
Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Physiol Res. 2019 Mar 6;68(1):17-24. doi: 10.33549/physiolres.933895. Epub 2018 Oct 23.
Parkinson's disease (PD), which is the second most common neurodegenerative disorder after Alzheimer's disease, is firstly defined after James Parkinson's report. It carries motor symptoms such as resting tremor, bradykinesia and rigidity of skeletal muscle and freezing of gait. Furthermore, non-motor symptoms such as cognitive and behavioral problems, besides sensory impairments are seen in the patients. However, they may also suffer from sleep disorders or autonomic dysfunction. Although there are some medications in order to symptomatic management, but unfortunately, scientist could not have found exact approaches to cure this disease. Hence, producing a model which can express the most pathophysiologic and behavioral aspects of the disease is a desire. In this paper, we aimed to describe the different models of Parkinson's disease in brief.
帕金森病（PD）是仅次于阿尔茨海默病的第二常见神经退行性疾病，它首先在詹姆斯·帕金森的报告之后被定义。它具有运动症状，如静止性震颤、运动迟缓、骨骼肌僵硬和步态冻结。此外，患者还会出现认知和行为问题等非运动症状以及感觉障碍。然而，他们也可能患有睡眠障碍或自主神经功能障碍。尽管有一些药物用于对症治疗，但不幸的是，科学家尚未找到治愈这种疾病的确切方法。因此，建立一个能够表达该疾病最主要病理生理和行为方面的模型是人们所期望的。在本文中，我们旨在简要描述帕金森病的不同模型。
