Meador K J, Loring D W, Nichols F T, Adams R J, Feldman E B
Department of Neurology, Medical College of Georgia, Augusta 30912.
South Med J. 1988 Aug;81(8):1042-6. doi: 10.1097/00007611-198808000-00024.
Virgil Sydenstricker was a member of a notable American family which included authoress Pearl S. Buck and the eminent epidemiologist Edgar Sydenstricker. Dr. Sydenstricker's contributions in the fields of hematology and nutritional disease are legion. His landmark work in sickle cell anemia characterized a definite symptom complex with specific hematologic findings and inheritance pattern. He wrote on the complications of malnutrition and attempted to delineate the specific effects of individual nutritional factors. Dr. Sydenstricker and his associate H. M. Cleckley first described the syndrome of niacin deficiency encephalopathy. Today, the syndrome is still occasionally reported. Niacin deficiency should be considered when unexplained acute confusional states or neurologic deficits occur in the setting of malnutrition, antituberculous drug use, or chronic partial nutritional deficiency with acute increase in metabolic demand.
维吉尔·西登斯特里克是一个著名美国家庭的成员，这个家庭包括女作家赛珍珠和杰出的流行病学家埃德加·西登斯特里克。西登斯特里克博士在血液学和营养疾病领域的贡献众多。他在镰状细胞贫血方面的里程碑式工作确定了一种具有特定血液学表现和遗传模式的明确症状复合体。他撰写了关于营养不良并发症的文章，并试图阐明个体营养因素的具体影响。西登斯特里克博士和他的同事H. M. 克莱克利首次描述了烟酸缺乏性脑病综合征。如今，该综合征仍偶尔有报道。当在营养不良、使用抗结核药物或慢性部分营养缺乏且代谢需求急性增加的情况下出现无法解释的急性意识模糊状态或神经功能缺损时，应考虑烟酸缺乏。
