Silberberg R
Department of Pathology, Hebrew University School of Medicine, Jerusalem.
Spine (Phila Pa 1976). 1988 Feb;13(2):202-8. doi: 10.1097/00007632-198802000-00013.
The trabecular bone of the vertebrae of 30 male and 30 female sand rats (Psammomys obesus) aged 13 to 33 months was examined histologically and morphometrically. The usual age-linked decline of bone mass failed to occur in females and was statistically not significant in males. A few changes with age were noted at the cellular level. Sex differences were statistically significant only in animals living into the third year of life, males having a smaller bone mass than females. This abnormality of the vertebral spongiosa is attributed to pathologic local stresses caused by the numerous instances of disc degeneration and herniation. Differences in size, location, and age of the herniations are thought to account for the wide fluctuations in the individual bone parameters examined. Whereas the spine of the sand rat provides an excellent model for the study of spondylosis, it is unsuited as a model for age-linked osteoporosis.
对30只年龄在13至33个月的雄性和30只雌性沙鼠（肥尾沙鼠）椎骨的小梁骨进行了组织学和形态计量学检查。雌性并未出现通常与年龄相关的骨量下降，雄性在统计学上也不显著。在细胞水平上发现了一些随年龄的变化。仅在活到第三年的动物中，性别差异具有统计学意义，雄性骨量小于雌性。椎骨松质骨的这种异常归因于椎间盘退变和突出的众多实例所引起的病理性局部应力。突出的大小、位置和年龄差异被认为是所检查的个体骨参数广泛波动的原因。虽然沙鼠的脊柱是研究脊椎病的极佳模型，但它不适合作为与年龄相关的骨质疏松症的模型。
