Silberberg R, Aufdermaur M, Adler J H
Arch Pathol Lab Med. 1979 May;103(5):231-5.
Aging sand rats (Psammomys obesus) kept on a standard laboratory diet supplemented by salt bush--their natural source of food--were examined for changes of the vertebral column. From about 6 months of age on, degeneration of the intervertebral disks was noted. The changes increased in severity with increasing age, and from 1 1/2 years of age on, massive multiple disk herniations were seen. Associated with these lesions were spondylosis of "intervertebral" as well as hyperostotic type, and osteoarthrosis of the apophyseal joint. The sand rat seems to be an excellent model for the study of the pathogenesis of spinal diseases associated with the aging process.
对以标准实验室饮食并添加盐生灌木（它们的天然食物来源）饲养的老龄沙鼠（肥尾心颅跳鼠）的脊柱变化进行了检查。从大约6个月龄开始，观察到椎间盘退变。这些变化的严重程度随着年龄增长而增加，并且从1.5岁开始，出现了大量多发椎间盘突出。与这些病变相关的有“椎间”型以及骨肥厚型的脊柱关节病，还有关节突关节的骨关节炎。沙鼠似乎是研究与衰老过程相关的脊柱疾病发病机制的理想模型。
