Ferrarini Zanetti Bianca, Paes de Almeida Ferreira Braga Daniela, Souza Setti Amanda, de Cássia Sávio Figueira Rita, Iaconelli Assumpto, Borges Edson
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP, 01401-002, Brazil; Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo, SP, 04503-040, Brazil.
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP, 01401-002, Brazil; Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo, SP, 04503-040, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2018 Dec;231:225-229. doi: 10.1016/j.ejogrb.2018.10.053. Epub 2018 Nov 2.
OBJECTIVE(S): To investigate the effect of perivitelline space (PVS) abnormalities on the outcomes of intracytoplasmic sperm injection (ICSI) cycles in which the entire cohort was affected.
Data from 9752 oocytes obtained from 1151 ICSI cycles performed from June/2010 to August/2016 in a private university-affiliated IVF centre. Cycles were divided into four groups according to the presence or absence of PVS abnormalities: PVS-L group (cycles with the entire oocyte cohort affected by large PVS, n = 265), PVS-G group (cycles with the entire oocyte cohort affected by PVS granularity, n = 280), PVS-L + PVS-G group (cycles with the entire oocyte cohort affected by PVS-L and PVS-G, n = 204), and control group (cycles with the entire oocyte cohort free of PVS abnormalities, n = 402). The effect of PVS abnormalities on ICSI outcomes was assessed by GLM adjusted for potential confounders.
Groups with PVS abnormalities presented substantially higher FSH/follicle (p < 0.001) and FSH/oocyte (p < 0.001) ratios, and lower numbers of follicles (p < 0.001), oocytes (p < 0.001) and embryos (p = 0.002) compared to the control group. PVS-L + PVS-G implantation (p = 0.044) and pregnancy (p = 0.004) rates were significantly lower than in cycles with isolated PVS abnormalities and controls.
CONCLUSION(S): Cycles in which the entire oocyte cohort is affected by both large PVS and PVS granularity have compromised implantation and pregnancy rates.
研究卵周间隙（PVS）异常对整个队列均受影响的卵胞浆内单精子注射（ICSI）周期结局的影响。
收集2010年6月至2016年8月在一所私立大学附属体外受精中心进行的1151个ICSI周期中获取的9752枚卵母细胞的数据。根据是否存在PVS异常将周期分为四组：PVS-L组（整个卵母细胞队列受大PVS影响的周期，n = 265），PVS-G组（整个卵母细胞队列受PVS颗粒度影响的周期，n = 280），PVS-L + PVS-G组（整个卵母细胞队列受PVS-L和PVS-G影响的周期，n = 204），以及对照组（整个卵母细胞队列无PVS异常的周期，n = 402）。通过对潜在混杂因素进行调整的广义线性模型（GLM）评估PVS异常对ICSI结局的影响。
与对照组相比，存在PVS异常的组FSH/卵泡（p < 0.001）和FSH/卵母细胞（p < 0.001）比值显著更高，而卵泡（p < 0.001）、卵母细胞（p < 0.001）和胚胎（p = 0.002）数量更低。PVS-L + PVS-G组的着床率（p = 0.044）和妊娠率（p = 0.004）显著低于孤立PVS异常周期和对照组。
整个卵母细胞队列受大PVS和PVS颗粒度共同影响的周期，其着床率和妊娠率受损。
