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J Assist Reprod Genet. 2020 Mar;37(3):693-697. doi: 10.1007/s10815-020-01704-x. Epub 2020 Feb 6.
2
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The destinies of human embryos reaching blastocyst stage between Day 4 and Day 7 diverge as early as fertilization.人类胚胎在受精后第 4 天至第 7 天达到囊胚阶段，其命运早在此时就已经分化。
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本文引用的文献

1
Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study.自然囊胚塌陷作为低妊娠结局的胚胎标志物：一项延时摄影研究。
JBRA Assist Reprod. 2020 Jan 30;24(1):34-40. doi: 10.5935/1518-0557.20190044.
2
Is perivitelline space morphology of the oocyte associated with pregnancy outcome in intracytoplasmic sperm injection cycles?卵母细胞的卵周隙形态与卵胞浆内单精子注射周期的妊娠结局有关吗？
Eur J Obstet Gynecol Reprod Biol. 2018 Dec;231:225-229. doi: 10.1016/j.ejogrb.2018.10.053. Epub 2018 Nov 2.
3
Potential of zygotes to produce live births can be identified by the size of the male and female pronuclei just before their membranes break down.在受精卵的膜破裂之前，可通过雄原核和雌原核的大小来确定其产生活产的潜力。
Reprod Med Biol. 2017 Apr 12;16(2):200-205. doi: 10.1002/rmb2.12032. eCollection 2017 Apr.
4
Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability.聚焦延时分析揭示了人类受精的新方面，并提出了胚胎活力的新参数。
Hum Reprod. 2018 Jan 1;33(1):23-31. doi: 10.1093/humrep/dex344.
5
Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber.作用于身份：成肌细胞融合和联体肌纤维的形成。
Semin Cell Dev Biol. 2017 Dec;72:45-55. doi: 10.1016/j.semcdb.2017.10.033. Epub 2017 Nov 6.
6
Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome.直接不等卵裂：胚胎发育能力、遗传构成与临床结局
PLoS One. 2016 Dec 1;11(12):e0166398. doi: 10.1371/journal.pone.0166398. eCollection 2016.
7
Impact of multinucleated blastomeres on embryo developmental competence, morphokinetics, and aneuploidy.多核胚胎碎片对胚胎发育能力、形态动力学和非整倍体的影响。
Fertil Steril. 2016 Sep 1;106(3):608-614.e2. doi: 10.1016/j.fertnstert.2016.04.041. Epub 2016 May 18.
8
Syncytium biogenesis: It's all about maintaining good connections.合胞体生物发生：一切都关乎维持良好的连接。
Worm. 2015 Jan 28;4(1):e992665. doi: 10.4161/21624054.2014.992665. eCollection 2015 Jan-Mar.
9
Oocyte zona pellucida dysmorphology is associated with diminished in-vitro fertilization success.卵母细胞透明带形态异常与体外受精成功率降低有关。
J Ovarian Res. 2015 Feb 27;8:5. doi: 10.1186/s13048-014-0111-5.
10
Diagnosis of human preimplantation embryo viability.人类胚胎植入前活力的诊断。
Hum Reprod Update. 2015 Nov-Dec;21(6):727-47. doi: 10.1093/humupd/dmu064. Epub 2015 Jan 6.

受精卵在体外受精后经过延时摄影系统观察到，在没有明显细胞分裂的情况下，发育成孵化的囊胚。

Blastulation of a zygote to a hatched blastocyst without any clear cell division: an observational finding in a time-lapse system after in vitro fertilization.

机构信息

IVF Laboratory, Kinderwunsch-MVZ Ulm GmbH, Einsteinstrasse 59, 89077, Ulm, Germany.

NextClinics International GmbH, 86482, Aystetten, Germany.

出版信息

J Assist Reprod Genet. 2020 Mar;37(3):693-697. doi: 10.1007/s10815-020-01704-x. Epub 2020 Feb 6.

DOI:10.1007/s10815-020-01704-x
PMID:32026203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7125290/
Abstract

PURPOSE

To describe an interesting not previously described morphokinetic finding.

METHODS

Retrospective case report of a couple undergoing controlled ovarian stimulation (COS) followed by in vitro fertilization and blastocyst transfer.

RESULTS

We identified a unique finding of blastulation of a fertilized human zygote after conventional in vitro fertilization. The fertilized zygote did not show any clear cytokinesis until approximately 107 h post insemination, when it started dividing into a blastocyst. By 113 h post insemination, inner cell mass and trophectoderm cells could be clearly distinguished and the blastocyst was completely hatched by 136 h post insemination.

CONCLUSION

Time-lapse systems offer more detailed observations of embryonic development. Here, we report an atypical development of an embryo that was not described previously. We hope to become an insightful discussion among peers and incentive the publication of such findings in the future.

摘要

目的

描述一个以前未描述的有趣的形态发生动力学发现。

方法

回顾性病例报告，一对夫妇接受控制性卵巢刺激（COS），然后进行体外受精和囊胚移植。

结果

我们发现了一个独特的受精人类合子囊胚形成的发现，这是在常规体外受精后发生的。受精后的合子直到大约受精后 107 小时才开始出现明显的胞质分裂，此时它开始分裂成囊胚。在受精后 113 小时，内细胞团和滋养外胚层细胞可以清楚地区分，囊胚在受精后 136 小时完全孵化。

结论

时程系统提供了对胚胎发育更详细的观察。在这里，我们报告了一个以前未描述的胚胎的非典型发育。我们希望这能成为同行之间有见地的讨论，并激励未来发表这样的发现。