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肥胖和孤独对 C 反应蛋白的叠加效应。

Additive effects of obesity and loneliness on C-reactive protein.

机构信息

Department of Health Behavior, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

出版信息

PLoS One. 2018 Nov 15;13(11):e0206092. doi: 10.1371/journal.pone.0206092. eCollection 2018.

DOI:10.1371/journal.pone.0206092
PMID:30439985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6237312/
Abstract

Obesity and loneliness are associated with C-reactive protein (CRP), a predictor of cardiovascular disease. It is unknown whether the co-presence of obesity and loneliness is associated with additional risk for clinically elevated CRP. The present study thus examines their independent and combined effects on elevated CRP in older adults. Data come from 10,912 respondents who completed the 2008 and 2010 waves of the Health and Retirement Study. Loneliness was measured using an 11-item Loneliness Scale and body mass index was calculated from technician measured height and weight. Our primary outcome is high sensitivity CRP (hsCRP). Survey-weighted logistic regression models were used to test whether loneliness and BMI category are independent predictors of CRP after adjusting for demographics and other inflammatory-related covariates. In the fully adjusted model for men, obesity (OR = 2.36, p < .0001) was associated with increased odds of hsCRP >3.0. Among females, being overweight (OR = 1.75, p < .0001) or obese (OR = 4.01, p < .0001) were associated increased odds of hsCRP>3.0. Among both men and women, results from fully adjusted models indicated that loneliness was not associated with clinically elevated hsCRP (OR = 1.34, p = .0535; OR = 0.97, p = 0.6776, respectively).

摘要

肥胖和孤独与 C 反应蛋白（CRP）有关，后者是心血管疾病的预测因子。目前尚不清楚肥胖和孤独同时存在是否会增加 CRP 升高的风险。本研究因此探讨了它们在老年人中对 CRP 升高的独立和综合影响。数据来自于完成了 2008 年和 2010 年健康与退休研究调查的 10912 名应答者。孤独感采用 11 项孤独量表进行测量，体重指数由技术人员测量的身高和体重计算得出。我们的主要结局是高敏 C 反应蛋白（hsCRP）。采用调查加权逻辑回归模型，在调整人口统计学和其他炎症相关协变量后，检验孤独感和 BMI 类别是否是 CRP 的独立预测因素。在男性的完全调整模型中，肥胖（OR=2.36，p<0.0001）与 hsCRP>3.0 的几率增加有关。对于女性，超重（OR=1.75，p<0.0001）或肥胖（OR=4.01，p<0.0001）与 hsCRP>3.0 的几率增加有关。在男性和女性中，完全调整模型的结果表明，孤独感与临床 hsCRP 升高无关（OR=1.34，p=0.0535；OR=0.97，p=0.6776）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/23c38ddfa8d5/pone.0206092.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/b7734b677d20/pone.0206092.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/9cbb87b8f430/pone.0206092.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/23c38ddfa8d5/pone.0206092.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/b7734b677d20/pone.0206092.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/9cbb87b8f430/pone.0206092.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd39/6237312/23c38ddfa8d5/pone.0206092.g003.jpg

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