磁共振波谱分析作为一种补充方法在临床环境下对脑部 MRI 的价值。
The value of magnetic resonance spectroscopy as a supplement to MRI of the brain in a clinical setting.
机构信息
Department of Radiology, Uppsala University, Uppsala, Sweden.
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
出版信息
PLoS One. 2018 Nov 15;13(11):e0207336. doi: 10.1371/journal.pone.0207336. eCollection 2018.
BACKGROUND
There are different opinions of the clinical value of MRS of the brain. In selected materials MRS has demonstrated good results for characterisation of both neoplastic and non-neoplastic lesions. The aim of this study was to evaluate the supplemental value of MR spectroscopy (MRS) in a clinical setting.
MATERIAL AND METHODS
MRI and MRS were re-evaluated in 208 cases with a clinically indicated MRS (cases with uncertain or insufficient information on MRI) and a confirmed diagnosis. Both single voxel spectroscopy (SVS) and chemical shift imaging (CSI) were performed in 105 cases, only SVS or CSI in 54 and 49 cases, respectively. Diagnoses were grouped into categories: non-neoplastic disease, low-grade tumour, and high-grade tumour. The clinical value of MRS was considered very beneficial if it provided the correct category or location when MRI did not, beneficial if it ruled out suspected diseases or was more specific than MRI, inconsequential if it provided the same level of information, or misleading if it provided less or incorrect information.
RESULTS
There were 70 non-neoplastic lesions, 43 low-grade tumours, and 95 high-grade tumours. For MRI, the category was correct in 130 cases (62%), indeterminate in 39 cases (19%), and incorrect in 39 cases (19%). Supplemented with MRS, 134 cases (64%) were correct, 23 cases (11%) indeterminate, and 51 (25%) incorrect. Additional information from MRS was beneficial or very beneficial in 31 cases (15%) and misleading in 36 cases (17%).
CONCLUSION
In most cases MRS did not add to the diagnostic value of MRI. In selected cases, MRS may be a valuable supplement to MRI.
背景
脑 MRS 的临床价值存在不同意见。在选定的材料中，MRS 已证明对肿瘤性和非肿瘤性病变的特征具有良好的效果。本研究的目的是评估磁共振波谱（MRS）在临床环境中的附加价值。
材料与方法
对 208 例临床提示有 MRS （MRI 上有不确定或信息不足的病例）和确诊病例进行 MRI 和 MRS 重新评估。105 例进行了单体素光谱（SVS）和化学位移成像（CSI），54 例和 49 例分别仅进行了 SVS 或 CSI。诊断分为非肿瘤性疾病、低级别肿瘤和高级别肿瘤。如果 MRS 在 MRI 上未提供正确的类别或位置，则认为其具有非常有益的临床价值；如果排除了可疑疾病或比 MRI 更具特异性，则认为其有益；如果提供的信息相同，则认为其无意义；如果提供的信息较少或不正确，则认为其具有误导性。
结果
70 例非肿瘤性病变，43 例低级别肿瘤，95 例高级别肿瘤。对于 MRI，130 例（62%）分类正确，39 例（19%）不确定，39 例（19%）错误。补充 MRS 后，134 例（64%）分类正确，23 例（11%）不确定，51 例（25%）错误。MRS 提供的额外信息在 31 例（15%）中有益或非常有益，在 36 例（17%）中具有误导性。
结论
在大多数情况下，MRS 并未增加 MRI 的诊断价值。在选定的病例中，MRS 可能是 MRI 的有价值的补充。
Zotero 插件