Park Youkyeong, Yun Jeong-Dae, Kim Jungsuk
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513397.
This paper presents a low-noise transimpedance amplifier (TIA) employing chopper-stabilized technique for nanopore applications. The TIA, which is used as a headstage for the monitoring system, must achieve low-noise performance to accurately measure a minute ionic current signal generated from the nanopore. In this work, we analyze detailed input- referred noise current of the capacitive-feedback TIA and propose a core amplifier adopting the chopper-stabilized technique to effectively reduce flicker noise in a bandwidth of interest for nanopore applications. This proposed circuit schematic is designed by harnessing 0.35 $\mu \mathrm{m}$ CMOS process and is verified using elaborate simulation results.
本文提出了一种采用斩波稳定技术的低噪声跨阻放大器（TIA），用于纳米孔应用。该TIA用作监测系统的前置放大器，必须具备低噪声性能，以准确测量纳米孔产生的微小离子电流信号。在这项工作中，我们详细分析了电容反馈TIA的输入参考噪声电流，并提出了一种采用斩波稳定技术的核心放大器，以有效降低纳米孔应用感兴趣带宽内的闪烁噪声。所提出的电路原理图采用0.35μm CMOS工艺进行设计，并通过详细的仿真结果进行了验证。
