一种用于生物纳米孔应用的集成式低噪声膜片钳放大器。
An integrated, low noise patch-clamp amplifier for biological nanopore applications.
作者信息
Wang Gang, Dunbar William B
机构信息
Computer Engineering, University of California, Santa Cruz, 1156 High Street, CA 95064, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2718-21. doi: 10.1109/IEMBS.2010.5626570.
We present an integrated, low noise patch-clamp amplifier for biological nanopore applications. Our amplifier consists of an integrator-differentiator architecture coupled with a novel opamp design in the CMOS 0.35 µm process. The post-layout full-chip simulation shows the input referred noise of the amplifier is 0.49 pA RMS over a 5 kHz bandwidth using a verified electrical model for the biological nanopore system. In our biological nanopore experiments studying protein-DNA interactions, we encounter capacitive transients with a nominal settling time of 5 ms. Our amplifier design reduces the settling time to 0.2 ms, without requiring any compensation circuitry.
我们展示了一种用于生物纳米孔应用的集成式低噪声膜片钳放大器。我们的放大器由积分-微分架构与采用0.35 µm CMOS工艺的新型运算放大器设计相结合而成。布局后全芯片仿真表明，使用经过验证的生物纳米孔系统电学模型，该放大器在5 kHz带宽上的输入参考噪声为0.49 pA RMS。在我们研究蛋白质- DNA相互作用的生物纳米孔实验中，我们遇到了标称建立时间为5 ms的电容瞬变。我们的放大器设计将建立时间缩短至0.2 ms，无需任何补偿电路。
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