Temporal Pattern of Ripple Events in Temporal Lobe Epilepsy: Towards a Pattern-based Localization of the Seizure Onset Zone.

Ripples (80-250 Hz) are brief high-frequency oscillations that are often detected in intracranial EEG (iEEG) and are currently investigated as a potential biomarker to facilitate the Iocalization of the seizure onset zone (SOZ) in patients with drug-resistant epilepsy. While the rate and shape of these oscillations have been positively correlated with the SOZ, the temporal pattern of these oscillations in the epileptic brain still requires investigation. In this study, we investigate the temporal pattern of ripple events in five patients with temporal lobe epilepsy (TLE), which is one of the most common forms of epilepsy. The rate of ripple events is positively correlated with the SOZ in TLE but its diagnostic utility in localizing the SOZ remains unclear, which suggests that additional ripple-related features should be investigated. By combining point process modeling and cluster analysis, we show that a recurrent, non-stationary bursting pattern characterizes the SOZ channels consistently across patients, while the non-SOZ channels have poor between-channel similarity and no consistent pattern over time nor across patients. Furthermore, the degree of separation between SOZ and non-SOZ model parameter vectors is significantly higher (ANOVA test, ${P}$-value $P\lt 0.01$) than the degree of separation between the ripple rates, which suggests that the temporal pattern more than the rate may contribute to the pre- surgical Iocalization of the SOZ.