Bauman W A, Maimen M, Langer O
Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, NY 10468.
Am J Obstet Gynecol. 1988 Aug;159(2):446-50. doi: 10.1016/s0002-9378(88)80105-4.
We studied 43 women in their third trimester of pregnancy whose fetuses were at significant risk of intrauterine growth retardation. To define metabolic subtypes for intrauterine growth retardation, a 100 gm glucose load was administered after an overnight fast. Twenty-seven women were normotensive and 16 had hypertension. The glucose tolerance of the hypertensive group was essentially the same as that of the normotensive group. However, 8 of the 16 women with hypertension had marked hyperinsulinemia in response to an oral glucose load. Of the five women with hypertension who gave birth to offspring of low birth weight, three had hyperinsulinemia.
我们研究了43名处于妊娠晚期的女性，她们的胎儿存在宫内生长迟缓的显著风险。为了定义宫内生长迟缓的代谢亚型，在禁食过夜后给予100克葡萄糖负荷。27名女性血压正常，16名患有高血压。高血压组的糖耐量与血压正常组基本相同。然而，16名患有高血压的女性中有8名在口服葡萄糖负荷后出现明显的高胰岛素血症。在5名患有高血压且产下低体重后代的女性中，有3名患有高胰岛素血症。
