Bagga R, Vasishta K, Majumdar S, Garg S K
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Aust N Z J Obstet Gynaecol. 1990 Nov;30(4):310-3. doi: 10.1111/j.1479-828x.1990.tb02017.x.
Twenty pregnant women with fetal growth retardation and 20 pregnant women with appropriate for gestational age fetuses (controls) were recruited after the 28th week of gestation. Samples were collected for estimation of serum insulin and human placental lactogen (HPL) levels in the fasting state and a glucose tolerance test was carried out on all the subjects. The results showed the glucose and HPL levels to be significantly lower in the fetal growth retardation group compared to controls. There were no differences in the fasting serum insulin levels in the 2 groups. Fetal growth retardation appears to be linked with the absence of development of the physiological 'diabetogenic' state in the second half of pregnancy. This maternal hypoglycaemic state is associated with low HPL levels and not with raised maternal insulin levels as measured in the fasting state.
20名胎儿生长受限的孕妇和20名孕龄胎儿正常的孕妇（对照组）在妊娠28周后被招募。采集样本以估计空腹状态下的血清胰岛素和人胎盘催乳素（HPL）水平，并对所有受试者进行葡萄糖耐量试验。结果显示，与对照组相比，胎儿生长受限组的葡萄糖和HPL水平显著降低。两组的空腹血清胰岛素水平没有差异。胎儿生长受限似乎与妊娠后半期生理性“致糖尿病”状态未发育有关。这种母亲低血糖状态与低HPL水平有关，而与空腹状态下测量的母亲胰岛素水平升高无关。
