Langer O, Damus K, Maiman M, Divon M, Levy J, Bauman W
Am J Obstet Gynecol. 1986 Oct;155(4):711-6. doi: 10.1016/s0002-9378(86)80004-7.
Early identification of the intrauterine growth-retarded fetus is a key factor in improving associated perinatal morbidity and mortality. We investigated, in a prospective study of 43 patients at high risk of intrauterine growth retardation, the predictive value of a derived glucose index and whether hypoglycemia accompanied by hypoinsulinemia in normotensive patients is associated with intrauterine growth retardation. Our findings suggest that the glucose index and 2-hour plasma glucose concentration appear to be useful antepartum predictors of intrauterine growth retardation in normotensive high-risk pregnancies. There is an apparent link between selective maternal hypoglycemia, hypoinsulinemia, and being small for gestational age. A "flat" glucose tolerance test should be regarded as an abnormal pattern in normotensive pregnancies as it was associated with a twentyfold increased risk of intrauterine growth retardation in this study.
早期识别宫内生长受限胎儿是改善相关围产期发病率和死亡率的关键因素。在一项对43例有宫内生长受限高风险患者的前瞻性研究中，我们调查了一个衍生葡萄糖指数的预测价值，以及血压正常的患者中伴有低胰岛素血症的低血糖是否与宫内生长受限有关。我们的研究结果表明，葡萄糖指数和2小时血浆葡萄糖浓度似乎是血压正常的高危妊娠中宫内生长受限有用的产前预测指标。选择性母体低血糖、低胰岛素血症与小于胎龄儿之间存在明显联系。在血压正常的妊娠中，“平坦”的葡萄糖耐量试验应被视为一种异常模式，因为在本研究中它与宫内生长受限风险增加20倍有关。
