Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:4026-4029. doi: 10.1109/EMBC.2017.8037739.
As one of the fastest-growing imaging modalities in recent years, photoacoustic imaging has attracted tremendous research interest for various applications including anatomical, functional and molecular imaging. Majority of the photoacoustic imaging systems are based on time-domain pulsed photoacoustic method, which utilizes pulsed laser source to induce wideband photoacoustic signal revealing optical absorption contrast. An alternative way is frequency-domain photoacoustic method utilizing chirping modulation of laser intensity to achieve lower system cost. In this paper, we report another way of photoacoustic method, called phase-domain photoacoustic sensing, which explores the phase difference between two consequent intensity-modulated laser pulses induced photoacoustic measurements to reveal the optical property. The basic principle is introduced, modelled and experimentally validated in this paper, which opens another potential pathway to perform photoacoustic sensing and imaging eliminating acoustic detection variations beyond the conventional time-domain and frequency-domain photoacoustic methods.
作为近年来发展最快的成像方式之一，光声成像在包括解剖学、功能和分子成像在内的各种应用中引起了极大的研究兴趣。大多数光声成像系统基于时域脉冲光声方法，该方法利用脉冲激光源来诱导宽带光声信号，揭示光吸收对比度。另一种方法是频域光声方法，利用激光强度的啁啾调制来降低系统成本。在本文中，我们报告了光声方法的另一种方式，称为相域光声传感，它探索两个连续强度调制激光脉冲诱导的光声测量之间的相位差，以揭示光学特性。本文介绍了其基本原理，进行了建模并通过实验验证，这为执行光声传感和成像开辟了另一条潜在途径，消除了传统时域和频域光声方法之外的声学检测变化。
