Williams Ashley J, Trumpis Michael, Bent Brinnae, Chiang Chia-Han, Viventi Jonathan
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5057-5060. doi: 10.1109/EMBC.2018.8513432.
Micro-electrocorticography (µECoG) is a minimally invasive neural interface that allows for recording from the surface of the brain with high spatial and temporal resolution [1], [2]. However, discerning multi-unit and local field potential (LFP) activity with potentially highly-correlated signals across a dense µECoG array can be challenging. Here we describe a novel µECoG design to compare the effect of referencing recordings to a local reference electrode and common average referencing (CAR). The filtering effect and the significant increase in signal to noise ratio of the evoked response (ESNR) can be seen after re-referencing for both types of referencing. In a preliminary analysis, re-referencing the µECoG signals can increase recording performance at high contact densities in the auditory cortex. This also provides promising evidence for a versatile in-house fabricated µECoG electrode.
微皮层脑电图(µECoG)是一种微创神经接口,能够以高空间和时间分辨率从大脑表面进行记录[1,2]。然而,在密集的µECoG阵列中辨别具有潜在高度相关信号的多单元和局部场电位(LFP)活动可能具有挑战性。在此,我们描述了一种新型µECoG设计,以比较将记录参考至局部参考电极和公共平均参考(CAR)的效果。对于这两种参考类型,重新参考后均可观察到滤波效果以及诱发反应的信噪比显著增加(ESNR)。在初步分析中,对µECoG信号进行重新参考可提高听觉皮层中高接触密度下的记录性能。这也为一种通用的内部制造的µECoG电极提供了有前景的证据。
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