Sargolzaei Saman, Cai Yan, Walker Melissa J, Hovda David A, Harris Neil G, Giza Christopher C
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5414-5417. doi: 10.1109/EMBC.2018.8513500.
Experimental models have been proven to be valuable tools to understand downstream cellular mechanisms of Traumatic Brain Injury (TBI). The models allow for reduction of confounding variables and tighter control of varying parameters. It has been recently reported that craniectomy induces pro-inflammatory responses, which therefore needs to be properly addressed given the fact that craniectomy is often considered a control procedure for experimental TBI models. The current study aims to determine whether a craniectomy induces alterations in Resting State Network (RSN) in a developmental rodent model. Functional Magnetic Resonance Imaging (fMRI) data-driven RSN show clusters of peak differences (left caudate putamen, somatosensory cortex, amygdala and piriform cortex) between craniectomy and control group, four days post-craniectomy. In addition, the Novel Object Recognition (NOR) task revealed impaired working memory in the craniectomy group. This evidence supports craniectomy-induced neurological changes which need to be carefully addressed, considering the frequent use of craniectomy as a control procedure for experimental models of TBI.
实验模型已被证明是理解创伤性脑损伤（TBI）下游细胞机制的宝贵工具。这些模型有助于减少混杂变量，并更严格地控制各种参数。最近有报道称颅骨切除术会引发促炎反应，鉴于颅骨切除术常被视为实验性TBI模型的对照程序，因此需要妥善处理这一问题。当前研究旨在确定在发育中的啮齿动物模型中，颅骨切除术是否会引起静息态网络（RSN）的改变。功能磁共振成像（fMRI）数据驱动的RSN显示，在颅骨切除术后四天，颅骨切除术组和对照组之间存在峰值差异簇（左侧尾状壳核、体感皮层、杏仁核和梨状皮层）。此外，新颖物体识别（NOR）任务显示颅骨切除术组的工作记忆受损。这一证据支持了颅骨切除术引起的神经学变化，考虑到颅骨切除术经常被用作TBI实验模型的对照程序，因此需要谨慎对待。
