Abel E L, Lee J A
Department of Obstetrics/Gynecology, Wayne State University, Detroit, Michigan.
Alcohol Clin Exp Res. 1988 Jun;12(3):349-55. doi: 10.1111/j.1530-0277.1988.tb00205.x.
Male mice consumed liquid alcohol diets containing 20, 10, or 0% ethanol-derived calories (EDC) for 56-61 days. Animals fed the 10 and 0% EDC diets were pair-fed to 20% EDC animals. A nontreated ad libitum group was included to assess the effects of pair-feeding. After treatment, males were bred to nontreated females. Litter size, birthweight, bodyweight at 21 or 55 days of age, and organ weights except for thymus were not affected by paternal alcohol ingestion. There was a dose-related decrease in activity at 20 and 24 days of age in an activity chamber and a dose-related decrease in serum testosterone levels at 55 days of age in male offspring sired by alcohol-consuming males. Offspring sired by males consuming the 20% EDC diet also required fewer trials to learn a passive avoidance task and had longer latencies to reach the choice point in a T maze.
雄性小鼠食用含有20%、10%或0%乙醇衍生热量（EDC）的液体酒精饮食，持续56 - 61天。喂食10%和0% EDC饮食的动物与喂食20% EDC饮食的动物进行配对喂食。设立一个未处理的自由采食组以评估配对喂食的影响。处理后，雄性小鼠与未处理的雌性小鼠交配。窝仔数、出生体重、21日龄或55日龄时的体重以及除胸腺外的器官重量均不受父本酒精摄入的影响。在活动箱中，20日龄和24日龄时，酒精摄入雄性所生雄性后代的活动量呈剂量相关下降；55日龄时，血清睾酮水平也呈剂量相关下降。食用20% EDC饮食的雄性所生后代在学习被动回避任务时所需试验次数更少，在T迷宫中到达选择点的潜伏期更长。
