Family Medicine, Department of Public Health and Clinical Medicine, Umeå University, SE-90187 Umeå, Sweden.
Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, SE-90187 Umeå, Sweden.
Nutr Res. 2018 Nov;59:29-35. doi: 10.1016/j.nutres.2018.07.009. Epub 2018 Jul 12.
There is increasing evidence that vitamin D status is associated with muscle function. Vitamin D deficiency is common in immigrants. We hypothesized that there was a positive association between vitamin D status and muscle strength in immigrants. The aim of this study was to examine associations between vitamin D status and muscle strength in an immigrant population in Sweden. All immigrants aged 25-65 years, born in 9 African or Middle East countries, and living in a district in Umeå (n = 1306) were invited. A total of 111 men and 105 women (16.5%) completed the study. Lower limb muscle strength was examined using a standardized muscle function indices of muscle strength. Grip strength was examined using a JAMAR hand dynamometer. Serum 25-hydroxyvitamin D [25(OH)D] was measured using liquid chromatography-tandem mass spectrometry. The analyses were adjusted for sex, age, height, body mass index, years since immigration, 25(OH)D, vitamin D deficiency, physical activity, and medical and socioeconomic factors. Twelve percent of the immigrants had vitamin D deficiency [25(OH)D levels <25 nmol/L]. In multivariable analyses, reduced lower limb muscle strength remained linearly associated with lower 25(OH)D concentrations (P = .008) and weaker grip strength remained associated with vitamin D deficiency (P = .022) after adjustments. The association between vitamin D deficiency and reduced lower limb muscle strength did not reach statistical significance (P = .052). The results demonstrate that vitamin D deficiency and low 25(OH)D concentrations were associated with muscle weakness in immigrants.
越来越多的证据表明,维生素 D 状态与肌肉功能有关。维生素 D 缺乏在移民中很常见。我们假设维生素 D 状态与移民的肌肉力量之间存在正相关关系。本研究的目的是在瑞典的移民人群中研究维生素 D 状态与肌肉力量之间的关系。邀请了所有 25-65 岁、出生于 9 个非洲或中东国家、居住在于默奥区的移民(n = 1306)。共有 111 名男性和 105 名女性(16.5%)完成了研究。使用标准化肌肉力量指数检查下肢肌肉力量。使用 JAMAR 手握测力计检查握力。使用液相色谱-串联质谱法测量血清 25-羟维生素 D [25(OH)D]。分析调整了性别、年龄、身高、体重指数、移民年限、25(OH)D、维生素 D 缺乏、体力活动以及医疗和社会经济因素。12%的移民存在维生素 D 缺乏症[25(OH)D 水平<25nmol/L]。在多变量分析中,在调整后,较低的下肢肌肉力量与较低的 25(OH)D 浓度呈线性相关(P =.008),较弱的握力与维生素 D 缺乏相关(P =.022)。维生素 D 缺乏症与下肢肌肉力量下降之间的关联没有达到统计学意义(P =.052)。结果表明,维生素 D 缺乏症和低 25(OH)D 浓度与移民的肌肉无力有关。