King's College London, Department of Twin Research & Genetic Epidemiology, South Wing St Thomas', London, UK.
School of Sports and Exercise Sciences, Faculty of Science, Liverpool John Moores University, Liverpool L3 3AF, UK.
Age Ageing. 2022 Apr 1;51(4). doi: 10.1093/ageing/afac079.
Clinical trials have suggested that increased 25-hydroxyvitamin D (25(OH)D) has positive effect on hand grip strength. This Mendelian randomisation (MR) was implemented using summary-level data from the largest genome-wide association studies on vitamin D (n = 73,699) and hand grip strength. Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, MR-Egger and leave-one-out were applied as sensitivity analysis. Results showed that genetically higher-serum 25(OH)D levels had a positive effect on both right hand grip (IVW = Beta: 0.038, P = 0.030) and left hand grip (IVW = Beta: 0.034, P = 0.036). There was a low likelihood (statistically insignificant) of heterogeneity and pleiotropy, and the observed associations were not driven by single single-nucleotide polymorphisms. Furthermore, MR pleiotropy residual sum and outlier did not highlight any outliers. In conclusion, our results highlighted the causal and beneficial effect of serum 25(OH) D on right- and left-hand grip strengths.
临床试验表明，25-羟维生素 D（25（OH）D）水平升高对握力有积极影响。本孟德尔随机化（MR）研究使用了维生素 D 最大全基因组关联研究的汇总水平数据（n=73699）和握力数据。采用逆方差加权法（IVW）估计因果效应。加权中位数（WM）法、MR-Egger 法和逐一剔除法作为敏感性分析。结果表明，血清 25（OH）D 水平升高与右手握力（IVW=Beta：0.038，P=0.030）和左手握力（IVW=Beta：0.034，P=0.036）均呈正相关。异质性和多效性的可能性较低（统计学上无显著性），且观察到的关联不受单个单核苷酸多态性的驱动。此外，MR 多效性残差和异常值未提示任何异常值。总之，本研究结果强调了血清 25（OH）D 对右手和左手握力的因果和有益作用。
