Yang Fan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Microbiol. 2018 Nov 1;9:2661. doi: 10.3389/fmicb.2018.02661. eCollection 2018.
Hepatitis B virus infection remains a global healthy issue that needs to be urgently solved. Novel strategies for anti-viral therapy are based on exploring the effective diagnostic markers and therapeutic targets of diseases caused by hepatitis B virus (HBV) infection. It is well-established that not only viral proteins themselves but also key factors from the host control the biological processes associated with HBV, including replication, transcription, packaging, and secretion. Protein post-translational modifications (PTMs), such as phosphorylation, acetylation, methylation, and ubiquitination, have been shown to control protein activity, regulate protein stability, promote protein interactions and alter protein subcellular localization, leading to the modulation of crucial signaling pathways and affected cellular processes. This review focuses on the functions and effects of diverse PTMs in regulating important processes in the HBV life cycle. The potential roles of PTMs in the pathogenesis of HBV-associated liver diseases are also discussed.
乙型肝炎病毒感染仍然是一个亟待解决的全球健康问题。抗病毒治疗的新策略基于探索由乙型肝炎病毒（HBV）感染引起的疾病的有效诊断标志物和治疗靶点。众所周知，不仅病毒蛋白本身，而且宿主的关键因子也控制着与HBV相关的生物学过程，包括复制、转录、包装和分泌。蛋白质翻译后修饰（PTM），如磷酸化、乙酰化、甲基化和泛素化，已被证明可控制蛋白质活性、调节蛋白质稳定性、促进蛋白质相互作用并改变蛋白质亚细胞定位，从而导致关键信号通路的调节和受影响的细胞过程。本综述重点关注不同PTM在调节HBV生命周期重要过程中的功能和作用。还讨论了PTM在HBV相关肝病发病机制中的潜在作用。
