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2
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.一种新型的奥维诺醇类似物BU08028，作为一种在灵长类动物中无滥用倾向的安全阿片类镇痛药。
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5511-8. doi: 10.1073/pnas.1605295113. Epub 2016 Aug 29.
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CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016.美国 2016 年慢性疼痛阿片类药物处方指南。
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Resilience moderates the association between chronic pain and depressive symptoms in the elderly.心理弹性调节老年人慢性疼痛与抑郁症状之间的关联。
Eur J Pain. 2016 Sep;20(8):1253-65. doi: 10.1002/ejp.850. Epub 2016 Feb 23.
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老年人慢性疼痛的管理：近期治疗进展概述

Managing Chronic Pain in the Elderly: An Overview of the Recent Therapeutic Advancements.

作者信息

Ali Asad, Arif Abdul Wahab, Bhan Chandur, Kumar Deepak, Malik Muhammad Bilal, Sayyed Zohaib, Akhtar Khawaja Hassan, Ahmad Malik Qistas

机构信息

Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, PAK.

Medicine, Shaikh Zayed Hospital, Lahore, PAK.

出版信息

Cureus. 2018 Sep 13;10(9):e3293. doi: 10.7759/cureus.3293.

DOI:10.7759/cureus.3293
PMID:30443463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6235641/
Abstract

A majority of the elderly suffer from chronic pain that significantly alters their daily activities and imposes an enormous burden on health care. Multiple comorbidities and the risk of polypharmacy in the elderly make it a challenge to determine the appropriate drug, dosage, and maintenance of therapy. Opioids are the most commonly used agents for this purpose in the elderly. The aim of this article is to discuss both the current well-established therapies used for managing chronic pain in the elderly and also the emerging newer therapies.

摘要

大多数老年人患有慢性疼痛，这严重改变了他们的日常活动，并给医疗保健带来了巨大负担。老年人的多种合并症和多重用药风险使得确定合适的药物、剂量和维持治疗成为一项挑战。阿片类药物是老年人为此目的最常用的药物。本文的目的是讨论目前用于管理老年人慢性疼痛的既定疗法以及新兴的新疗法。