Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Department of Physics and Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
Angew Chem Int Ed Engl. 2019 Jan 14;58(3):769-774. doi: 10.1002/anie.201810878. Epub 2018 Dec 13.
Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti-cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis- and autophagy-mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti-cancer agents and reveals a new direction for nanomedicine research.
黑磷纳米片（BPs）由于其固有的、选择性的化学治疗作用，被证明是一种高度生物活性的抗癌剂。由于更强的细胞内氧化应激和加速的能量代谢，不同类型的癌细胞中观察到 BPs 的快速细胞内生物降解和磷酸盐阴离子的急剧升高，而正常细胞不受影响。BPs 的选择性生物降解导致癌细胞出现 G2/M 期阻滞，随后通过细胞凋亡和自噬介导的细胞死亡，而正常细胞则不受影响。其选择性优于传统化疗药物阿霉素（DOX）。体内评估证实了 BPs 在抑制肿瘤生长方面的功效。本研究为纳米结构生物活性抗癌剂提供了新的见解，并为纳米医学研究开辟了新的方向。
