State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
School of Life Sciences, Nanjing University, Nanjing, China.
Angew Chem Int Ed Engl. 2021 May 25;60(22):12524-12531. doi: 10.1002/anie.202101486. Epub 2021 Apr 21.
Among phosphorus-based nanomaterials, layered black phosphorus and violet phosphorus have been actively explored in the past decade. However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in vitro and in vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy-mediated cell death in a shape-dependent manner. Our findings provide a method for construction of layered RP nanomaterials and they present a unique mechanism for the application of phosphorus-based materials in nanomedicines.
在基于磷的纳米材料中，层状黑磷和紫磷在过去十年中得到了积极的探索。然而，对于红磷纳米片（RPNSs）的合成方法却一直缺乏研究，尽管红磷（RP）在商业上价格低廉且在室温下具有优异的化学稳定性。我们报告了一种使用半胱氨酸作为还原剂制备 RPNSs 和掺杂 RPNSs 的有效策略。体外和体内研究的数据表明，RPNSs 可以以形状依赖的方式触发活性氧物质的产生、DNA 损伤以及随后的自噬介导的细胞死亡。我们的发现为构建层状 RP 纳米材料提供了一种方法，并为磷基材料在纳米医学中的应用提供了一种独特的机制。
