Zhu Jianmeng, Wang Hongqin, Li Kaiqiang, Yuan Xiuze, Hong Wenzhong
Clinical Laboratory of Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Hangzhou, Zhejiang, People's Republic of China.
Laboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Int J Nanomedicine. 2024 Nov 26;19:12583-12592. doi: 10.2147/IJN.S414938. eCollection 2024.
Conventional treatments for hepatocellular carcinoma (HCC) lack efficacy and targeting abilities. Photodynamic therapy (PDT) has emerged as a promising alternative for targeted and minimally invasive tumor treatments. However, many biomaterials used in PDT pose biosafety concerns and insufficient enzyme activity often leads to limited reactive oxygen species (ROS) production, resulting in poor PDT efficacy. Single-atom nanoenzymes have attracted much research attention as a novel type of high-performance nanoenzymes.
In this study, we prepared black phosphorus nanosheets (BP) with good biocompatibility as a platform and loaded single-atom gold nanoenzymes onto BP nanosheets to treat HCC. To enhance the stability and targeting ability of the nanohybrid, it was PEGylated and modified with folate (FA) targeting molecules.
The designed BP/single-atom nanoenzyme platform can target tumor tissues and generate substantial amounts of reactive oxygen species (ROS), demonstrating biocompatibility and improved catalytic activity.
The nanoplatform effectively targets HCC and enhances PDT efficacy by increasing ROS production, offering a promising approach for HCC treatment.
肝细胞癌（HCC）的传统治疗方法缺乏疗效和靶向能力。光动力疗法（PDT）已成为一种有前景的靶向和微创肿瘤治疗替代方法。然而，许多用于PDT的生物材料存在生物安全问题，且酶活性不足往往导致活性氧（ROS）产生受限，从而导致PDT疗效不佳。单原子纳米酶作为一种新型高性能纳米酶已引起众多研究关注。
在本研究中，我们制备了具有良好生物相容性的黑磷纳米片（BP）作为平台，并将单原子金纳米酶负载到BP纳米片上以治疗HCC。为提高纳米杂化物的稳定性和靶向能力，对其进行聚乙二醇化并用叶酸（FA）靶向分子修饰。
所设计的BP/单原子纳米酶平台可靶向肿瘤组织并产生大量活性氧（ROS），显示出生物相容性和改善的催化活性。
该纳米平台通过增加ROS产生有效靶向HCC并提高PDT疗效，为HCC治疗提供了一种有前景的方法。
