Düzgüneş Nejat, Piskorz Jaroslaw, Skupin-Mrugalska Paulina, Goslinski Tomasz, Mielcarek Jadwiga, Konopka Krystyna
Department of Biomedical Sciences, Arthur A Dugoni School of Dentistry, University of the Pacific, 155 Fifth Street, San Francisco, CA 94103, USA.
Department of Inorganic & Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Ther Deliv. 2018 Nov;9(11):823-832. doi: 10.4155/tde-2018-0050.
The photodynamic reaction involves the light-induced generation of an excited state in a photosensitizer molecule (PS), which then results in the formation of reactive oxygen species in the presence of oxygen, or a direct modification of a cellular molecule. Most PSs are porphyrinoids, which are highly lipophilic, and are administered usually in liposomes to facilitate their effective delivery to target cells. The currently available liposomal formulations are Visudyne and Fospeg. Novel PSs were developed and tested for their photodynamic activity against cancer cells. Several compounds were highly phototoxic to oral cancer cells both in free and liposome-encapsulated form, with nanomolar IC values. The lowest ICs (7-13 nM) were obtained with a PS encapsulated in cationic liposomes.
光动力反应涉及光诱导光敏剂分子（PS）产生激发态，然后在有氧存在的情况下导致活性氧的形成，或对细胞分子进行直接修饰。大多数PS是卟啉类化合物，具有高度亲脂性，通常通过脂质体给药以促进其有效递送至靶细胞。目前可用的脂质体制剂有维速达尔和福斯泊。开发了新型PS并测试了它们对癌细胞的光动力活性。几种化合物以游离形式和脂质体包裹形式对口腔癌细胞均具有高光毒性，其半数抑制浓度（IC）值为纳摩尔级别。用阳离子脂质体包裹的PS获得了最低的IC值（7 - 13 nM）。
